Scientist I, Large Molecule Bioanalysis LC-MS

Neurocrine Biosciences • San Diego, CA

3d

About The Position

Neurocrine Biosciences is seeking a Scientist in Large Molecule Bioanalysis to support preclinical development of peptides, antibodies, proteins, ADCs, and other protein conjugates. The role will primarily involve hands-on development and application of hybrid LC-MS/MS and LC-HRMS methods for quantitative bioanalysis and biotransformation assessment.

Requirements

• BS in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related field
• 2+ years of relevant experience in bioanalysis or MS
• Hands-on experience with LC-MS analysis of proteins or peptides in plasma, serum, tissue, or other biological matrices
• Experience with hybrid LC-MS, immunoaffinity workflows, protein digestion, and high-resolution MS
• Experience with peptide/protein quantitation and bioanalytical method development

Nice To Haves

• Some industry experience preferred
• Experience supporting preclinical bioanalysis and/or GLP method transfer is preferred
• Familiarity with Skyline, Analyst, TraceFinder, Chromeleon, or BioPharma Finder is beneficial

Responsibilities

• Develop and apply hybrid LC-MS/MS and LC-HRMS methods for peptide and protein quantitation in biological matrices
• Develop, optimize, and apply hybrid LC-MS/MS and LC-HRMS methods for peptide and protein quantitation in biological matrices
• Support bioanalysis of samples from preclinical PK/TK and other nonclinical studies
• Perform immunoprecipitation/immunoaffinity enrichment, protein digestion, and surrogate peptide quantitation
• Perform intact protein analysis, peptide mapping, and bottom-up LC-HRMS analysis
• Support biotransformation assessment of ADCs and protein conjugates using hybrid LC-HRMS
• Analyze, document, and communicate experimental results and contribute to method improvements

Benefits

• Annual bonus with a target of 20% of the earned base salary
• Eligibility to participate in our equity based long term incentive program
• Retirement savings plan (with company match)
• Paid vacation, holiday and personal days
• Paid caregiver/parental and medical leave
• Health benefits to include medical, prescription drug, dental and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level