Scientist I/II, Gene Therapy Drug Discovery B
About The Position
Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases. We are seeking a highly skilled and motivated bench scientist to join the Molecular Therapeutics team to select our lead therapeutics. The ideal candidate will have a strong scientific background in human iPSC biology, animal husbandry, in vivo biodistribution studies (small and large animal), protein science, molecular biology, and quantitative imaging techniques.
Requirements
- PhD in Physiology, Pharmacology, Virology, or another related discipline and 0-4+ years of relevant experience preferred
- Or: MS and 6-8+ years of relevant experience; BS and 8-10+ years of relevant experience
- Strong track record in experimental design, animal husbandry, molecular genetics and cellular biology, statistics, protein science, and imaging
- Proficient in methods for quantitative analysis of nucleic acid and protein including nucleic acid extraction, ddPCR, ELISA, and MSD
- Hands-on experience with performing dosing and tissue collection procedures with mouse models is desirable
- Proficiency in computing include Geneious, Endnote, BLAST, Ensembl, NCBI, Uniprot, UCSC, GTEx, Microsoft, PRISM statistics program, Benchling
- Strong problem-solving skills and the ability to work independently and collaboratively
- Excellent communication and presentation skills
Nice To Haves
- Familiarity with lab automation systems is a plus
- Hands-on experience with performing dosing and tissue collection procedures with mouse models is desirable
Responsibilities
- Contribute to both the inception and selection of AAV libraries
- Optimize in vitro and in vivo models to select lead therapeutics for translation to humans
- Design and manage animal studies at contract vivariums and CROs
- Quantitatively compare VG, mRNA, and protein levels in cells and tissues
- Detailed understanding of antibody and FISH imaging techniques to quantify biodistribution and expression levels
- Collaborate within the MTx Department and across the R&D organization to incorporate selected therapies into the Discovery & Translational Development pipeline
- Communicate findings and insights to stakeholders through presentations, patents, publications, and scientific conferences
Benefits
- Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs
- 401(k) program participation with competitive company matched contributions
- Eligibility to participate in Solid’s Employee Stock Purchase Plan
- Mobile phone subsidy for eligible employees
- Tuition Reimbursement
- Vision Coverage
- Life Insurance
- Voluntary Pet Insurance
- Employee Discount Program on Travel, Entertainment, and Services
- Employee Assistance Programs
- Daily Subsidized Lunch Delivery (onsite @ Hood Park)
- Free Onsite Full-Service Gym (onsite @ Hood Park)
- Employee Parking (onsite @ Hood Park)
- 12 Observed Holidays and a winter shut down
- 15-day PTO Policy and an 80-hour rollover YoY
- 40-hour Sick Policy
- 8 Hour Floating Holiday
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
