Scientist I, Histology

Arrowhead Pharmaceuticals•San Diego, CA

4d•$115,000 - $125,000•Onsite

About The Position

The Scientist I is a key contributor to the Histotechnology team within the Biology Department. In partnership with the Histology Manager and cross-functional study teams, this role supports preclinical drug-development programs by planning and executing tissue collection strategies; processing, embedding, and sectioning specimens; performing histologic and immunohistochemical stains; and summarizing results for study teams. The Scientist I execute a broad range of routine and non-routine histology methods with consistent quality and reproducibility, communicates clearly with stakeholders, and exercises appropriate independence in day-to-day decision making. This role is onsite 5 days a week in San Diego.

Requirements

BS or MS degree in Cell Biology, Molecular Biology, Biochemistry, or related discipline.
BS with a minimum of seven (7) years relevant histology laboratory experience or a MS with 3+ years of academic/industry laboratory experience.
Proficiency with microtomes, cryostats, cassette/slide printers, automated slide stainers, and microscopes; practical knowledge of tissue composition.
Extensive experience in IHC/IF staining, protocol development, validation, and troubleshooting (including antibody titration and antigen retrieval).
Strong project- and time-management skills with the ability to manage multiple studies and deadlines; effective written and verbal communication.
Advanced computer skills (e.g., Excel and imaging software).
Ability to process valuable/delicate samples and to prepare tissue for pathologist interpretation.
Candidates must have current, valid authorization to work in the country where this role is located.

Nice To Haves

Degree from an accredited Histotechnology program, HT or HTL(ASCP) certification
Experience validating RNAscope/miRNAscope and multiplex IHC/IF across multiple tissues/species.
Familiarity with LIMS/ELN.
Familiarity with digital pathology and whole-slide imaging

Responsibilities

Translate study requirements into practical histology work plans (sampling schemes, section levels, stain menus, controls, timelines) and present interim results to program stakeholders.
Coordinate specimen receipt, accessioning, labeling/barcoding, and chain-of-custody; maintain complete, accurate, audit-ready records in LIMS/ELN or designated systems.
Perform routine automated tissue processing and paraffin embedding; microtome and cryosection a range of animal tissues at 5–7 µm; complete re-cuts and serial levels as needed with minimal artifacts.
Execute H&E, special stains, and IHC/IF on manual and automated platforms, including antigen retrieval, antibody titration, protocol design, and troubleshooting; contribute to method validation (e.g., RNAscope/miRNAscope, multiplex IHC/IF).
Perform microscopic QC, identify representative regions, and use imaging/slide scanning as available to support digital pathology; compile clear data summaries and presentations for study leads.
Adhere to SOPs and applicable quality expectations; follow biosafety and chemical-safety procedures; participate in deviations/CAPA as appropriate; contribute to team-based improvements (e.g., 5S/Lean).
Operate and perform routine maintenance/calibration checks for microtomes, cryostats, stainers, printers, microscopes; track reagents/antibodies and coordinate ordering and lot qualification.