Scientist I, Drug Product

Revolution Medicines•Redwood City, CA

1d•Onsite

About The Position

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The successful candidate will contribute to formulation and process development activities from early-stage through late-stage clinical/commercial development, working closely with cross-functional partners and CDMOs to ensure robust, scalable, and compliant drug product manufacturing processes.

Requirements

A degree in Pharmaceutical Science, Chemistry, Chemical Engineering, or closely related field is desirable.
Ph.D. with 0-2 years of experience or a bachelor’s/master’s degree with appropriate experience in the pharmaceutical/biotech industry settings.
Academic or research experience relevant to drug product development, formulation, pharmaceutical sciences, or small molecule development is preferred.
Knowledge of solid oral dosage forms, formulation principles, and pharmaceutical manufacturing processes gained through graduate research, coursework, internships, or related training is desirable.
Familiarity with formulation and process development concepts for small molecule drug products is preferred.
Basic understanding of pharmaceutical development, CMC principles, and global regulatory guidelines, including ICH guidelines, is desirable.
Exposure to working in multidisciplinary or collaborative research environments, including interactions with internal or external scientific partners, is a plus.
Strong scientific, technical writing, communication, and problem-solving skills.
Demonstrated ability to analyze experimental data, draw scientifically sound conclusions, and communicate results effectively.
Ability to learn quickly, manage multiple priorities, and work effectively in a fast-paced, innovation-driven, collaborative environment.

Nice To Haves

Ph.D. degree in Pharmaceutical Science, Chemistry, Chemical Engineering, or closely related field is desirable.

Responsibilities

Contribute to drug product development activities for new chemical entities (NCEs) from early development through late-stage clinical development, with exposure to commercialization activities.
Design and execute drug product development and manufacturing activities for solid oral dosage forms, including: Preformulation and formulation development, Manufacturing process development, Process scale-up, technology transfer, and process optimization, Process validation and commercial manufacturing support.
Support outsourced development and GMP drug product manufacturing activities at CDMOs including manufacturing oversight and troubleshooting.
Design and execute experiments, analyze and interpret data and present results and conclusions to project teams.
Work independently with limited supervision to conduct appropriate research and troubleshoot technical challenges, escalating complex issues as needed.
Author and contribute to CMC documentation for regulatory submissions (e.g., INDs, NDAs, MAAs) and internal technical reports.
Collaborate cross-functionally within CMC team (Clinical Supply, Analytical Development/QC, Quality Assurance, Drug Substance, Regulatory Affairs, and Project Management) and at enterprise level research/clinical/commercial teams to support aligned development strategy and execution.
Travel up to 20% to CRO/CDMO sites to support and oversee development and manufacturing operations.