Scientist I, Disease Biology

Altos Labs • San Francisco, CA

12h • $134,700 - $172,700

About The Position

We are looking for a talented and versatile Scientist I to join Discovery Science at Altos Labs. Our team uses functional genomics to unravel the deep biology of cellular rejuvenation and to restore cell health and resilience. In this role you will develop physiologically relevant in vitro and ex vivo disease models and integrate these with in vivo studies to identify interventions that reverse disease-associated cell states. If you have a strong foundation in molecular, cell, and disease biology, hands-on experience with in vitro and in vivo disease assays, and a passion for reversing disease states, we’d love to have you on the team.

Requirements

• PhD in Biology, Cell Biology, Physiology, or a related field, with 0-3 years of post-PhD experience.
• Proven track record of elucidating complex age-associated disease mechanisms, including but not limited to kidney, lung, liver and skin indications.
• Experience developing and validating cell-based disease assays, including benchmarking assay performance.
• Strong hands-on experience conceptualizing and performing rodent in vivo disease assays, with a background in relevant laboratory techniques and methods.
• Excellent professional writing skills and the ability to communicate through writing and presentations to a variety of audiences, from senior executives to entry-level employees.
• Problem-solving skills sufficient to identify issues, conduct research, and develop innovative solutions.
• Ability to maintain cooperative working relationships with a broad range of people, including staff colleagues, lab members, faculty, outside agencies and collaborators, and the community.
• Demonstrated high productivity and ability to complete work in a timely manner.
• Ability to organize work and set priorities.
• Ability to focus on details to produce accurate, quality work driven by deadlines.
• Ability to work in a dynamic environment and with others in a team.
• Strengths in dealing with ambiguity.

Nice To Haves

• Background in aging biology, regeneration, fibrosis, inflammation, metabolic disease, neurodegeneration, or related therapeutic areas.
• Experience dissecting mechanisms of action for candidate interventions (gene targets, small molecules, peptides, or other biologics).
• Experience developing and optimizing high-throughput screening and/or functional genomics assays.
• Direct experience with in vivo lung, kidney, liver or endothelial chronic disease models.
• Experience in computational biology and bioinformatics.

Responsibilities

• Design and execute innovative research strategies to identify causal regulators of cell state, aging, regeneration, and disease biology.
• Develop, benchmark, and validate disease cell models of age-related and disease-associated cell states.
• Scale assays to screen candidate interventions across cell models, and contribute to data-driven prioritization decisions on which candidates and which models to advance.
• Design, conduct, and interpret in vivo studies to evaluate candidate interventions and benchmark disease models against in vitro findings.
• Elucidate the mechanisms of action underlying promising interventions to identify and prioritize therapeutic targets and modalities.
• Support and manage internal/external collaborations across one or more multidisciplinary projects to accelerate essential research activities.
• Develop project-specific experimental strategies, techniques, and procedures.
• Collaborate closely with other scientists and cross-functional teams to integrate multidimensional datasets and generate actionable biological insight.
• Contribute to the writing and dissemination of research results.

Benefits

• Equal employment opportunities to all employees and applicants for employment, without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree