Scientist I, Analytical Development

Solid Biosciences • Boston, MA

1d • $125,000 - $140,000 • Onsite

About The Position

Solid Biosciences is seeking an experienced Scientist I to join the Analytical Development team. This individual will be responsible for the development, qualification, and operational support of analytical cell-based assays for Solid’s (pre)clinical gene therapy portfolio. The role will focus on cell-based analytical assay development with various read-outs and requires the ability to independently drive assay development with limited oversight. The position is on-site and reports to the Senior Scientist, Analytical Development.

Requirements

• PhD in cell biology, biotechnology, or relevant field with 0-2+ years of relevant industry experience, OR MS with 4-6+ years of relevant experience.
• Excellent communication, technical, and organizational skills.
• Must be a team player and embrace an interactive team-based culture.
• Strong understanding of basic cell biology, cellular pathways, and cell growth parameters.
• Extensive hands-on experience in mammalian cell culture, cell line characterization, cell-based assay development, and cell banking.
• Proven ability to develop cell-based potency assays in an industrial environment, including MOA based assay design, development, implementation, and qualification using ICH Q2 guidelines.
• Extensive experience with plate-based readouts (including ELISA, MSD and ICW).
• Hands-on experience with relevant analytical / statistical software suites, e.g. PLA, JMP, Softmax Pro.
• Self-motivator driven to deliver quality results within project timelines.
• Proven troubleshooting, problem solving and investigational skills.

Nice To Haves

• Experience in developing potency assays and analysis of AAV or similar viral vectors.
• Familiar with Solid’s disease areas of interest (DMD, FA, CPVT, etc.).

Responsibilities

• Drive the design and implementation of cell-based and functional potency assays to support the Solid Biosciences gene therapy portfolio.
• Support the development and execution of cell-based assays aligned with process development and cGMP manufacturing of Solid Biosciences’ lead candidates.
• Contribute to laboratory operations, including routine and non-routine analytical testing, and coordinate activities with internal Process Development and Vector Core Manufacturing teams.
• Author and review SOPs, technical reports, and regulatory documents to support development programs and submissions.
• Manage laboratory equipment and inventory, and compile, analyze, and present data to support process development and cross-functional teams.
• Maintain accurate and well-documented analytical records, including electronic laboratory notebooks.
• Mentor, and train junior scientists in cell-based analytical method development as needed.
• Perform additional duties and contribute to ad hoc projects as required.

Benefits

• Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs
• 401(k) program participation with competitive company matched contributions
• Eligibility to participate in Solid’s Employee Stock Purchase Plan
• Mobile phone subsidy for eligible employees
• Tuition Reimbursement
• Vision Coverage
• Life Insurance
• Voluntary Pet Insurance
• Employee Discount Program on Travel, Entertainment, and Services
• Employee Assistance Programs
• Daily Subsidized Lunch Delivery (onsite @ Hood Park)
• Free Onsite Full-Service Gym (onsite @ Hood Park)
• Employee Parking (onsite @ Hood Park)
• 12 Observed Holidays and a winter shut down
• 15-day PTO Policy and an 80-hour rollover YoY
• 40-hour Sick Policy
• 8 Hour Floating Holiday

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree