Scientist – Histology

Bristol Myers Squibb • San Diego, CA

7d • Onsite

About The Position

RayzeBio, a wholly owned subsidiary of Bristol Myers Squibb, is seeking a Histology Scientist to join its Translational team in a laboratory-based role supporting radiopharmaceutical therapies from preclinical research through translational development and clinical testing. The position focuses on processing FFPE and frozen specimens from treated preclinical models and human research tissues, and developing and performing tissue-based assays for target validation, biodistribution, pharmacodynamic, and mechanism-of-action investigations across pipeline programs.

The successful candidate will independently develop, optimize, troubleshoot, and interpret histology, immunohistochemistry (IHC), and immunofluorescence (IF) workflows and data. They will own and improve internal research histology capabilities, act as a histology subject-matter expert for cross-functional teams, and work with external CROs on assay development and related activities. The role also requires careful handling of laboratory reagents and, where applicable, radioactive specimens in accordance with safety and regulatory guidelines.

This is an onsite position in San Diego, California. The stated salary range is $118,259–$143,302. Additional discretionary cash incentives and stock opportunities may be available. Benefits may include wellbeing support, retirement and financial protection benefits, medical, dental, vision, life and disability insurance, flexible time off for eligible exempt employees, paid holidays, and other time-off benefits depending on eligibility.

Requirements

• B.S. or M.S. degree in Histotechnology, Biology, Biomedical Sciences, or a related field.
• 8–10 years of hands-on histology experience.
• Deep expertise in histology and tissue-based assay workflows, including optimization, troubleshooting, quality, and reproducibility.
• Hands-on experience processing, embedding, and microtome-sectioning FFPE tissue.
• Experience preparing, processing, and sectioning cell pellets as FFPE blocks.
• Hands-on experience preparing frozen tissue and performing cryosectioning.
• Experience conducting H&E and other routine histochemical stains.
• Experience designing, conducting, troubleshooting, and interpreting IHC and IF studies on FFPE and frozen tissue sections.
• Experience operating automated tissue stainers, such as Leica systems.
• Understanding of antibody optimization, antigen retrieval methods, and appropriate staining controls.
• Ability to independently troubleshoot staining and technical issues and clearly interpret and communicate histology data.
• Strong attention to detail and organizational skills, with the ability to maintain accurate laboratory records.
• Ability to work effectively in interdisciplinary drug discovery teams.
• Experience managing CROs, including study design, protocol review, data interpretation, vendor oversight, timeline management, and coordination of outsourced histology, pathology, and translational research.
• Ability to work with radioactive materials while strictly following radiation safety protocols, where applicable.
• Ability to independently design and optimize histology/IHC studies, interpret complex results, and recommend appropriate next steps.
• Ability to provide technical and scientific guidance to cross-functional teams and influence study design and experimental decisions within the area of expertise.
• Ability to independently manage multiple studies and priorities and drive work from study planning through data interpretation and reporting.

Nice To Haves

• HT or HTL (ASCP) certification.
• Experience with image analysis or digital pathology software such as HALO, QuPath, Visiopharm, or ImageJ/Fiji.
• Experience with multiplex IHC/IF staining platforms.
• Familiarity with whole slide scanning and digital slide management systems.
• Experience supporting drug discovery, target validation, or biodistribution studies in a pharmaceutical or biotechnology setting.
• Experience handling radioactive materials.
• Experience establishing or expanding histology/IHC capabilities, workflows, or assay platforms.

Responsibilities

• Process, embed, and microtome-section FFPE tissue blocks.
• Prepare, process, embed, section, and stain cell pellets as FFPE blocks.
• Prepare and section frozen tissue specimens using a cryostat.
• Conduct H&E and other routine histochemical stains to assess tissue morphology and quality.
• Design, perform, troubleshoot, and interpret IHC and IF studies on FFPE and frozen tissue sections.
• Operate and maintain automated tissue stainers to ensure consistent, reproducible staining.
• Optimize antibody titration, antigen retrieval, and staining protocols, including positive and negative controls.
• Acquire, analyze, and interpret histology and imaging data using image analysis and digital pathology software.
• Document tissue processing, staining protocols, and experimental results accurately.
• Collaborate with translational, in vivo, imaging, and biology teams on study design, tissue collection and preservation, sampling, assays, controls, endpoints, execution, and data interpretation.
• Maintain and troubleshoot histology equipment, including microtomes, cryostats, and automated stainers; coordinate service and calibration as needed.
• Manage sample inventory and traceability for frozen and FFPE blocks, slides, and cell samples.
• Work with CROs on IHC research assay development, troubleshooting, data transfer, and knowledge transfer.
• Serve as the histology subject-matter expert, providing scientific and technical guidance to cross-functional project teams.
• Safely handle laboratory reagents and, where applicable, radioactive tissue specimens in accordance with laboratory and regulatory guidelines.
• Independently interpret histology and IHC data and provide scientific recommendations to project teams.
• Own and continuously improve internal research histology capabilities and workflows.
• Manage multiple studies and priorities from planning through data interpretation and reporting.

Benefits

• Wellbeing support.
• Retirement and financial protection benefits.
• Medical, dental, vision, life, and disability insurance offerings.
• Flexible Time Off (FTO) without a set accrual limit for eligible U.S.-based exempt employees, subject to manager approval.
• 11 paid company holidays each year.
• For eligible employees, additional time-off benefits may include paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees may receive an annual Global Shutdown between Christmas Day and New Year's Day.
• Additional discretionary incentive cash and stock opportunities may be available.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior