Scientist, Early Bioprocess Research

AstraZeneca • Seattle, WA

3d • Onsite

About The Position

Here at AstraZeneca, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health and help fight and cure disease. As a Scientist, Early Bioprocess Research in the Early Infectious Disease (Early ID ) in Seattle, WA, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives. The Early ID team at AstraZeneca is discovering and developing novel vaccines and biologics targeting key viral pathogens. We are consistently pushing the boundaries of science to deliver life-changing medicines to patients. Our deep expertise in virology, bacteriology, immunology, and vaccines enables our ability to advance novel therapeutic approaches and technologies to prevent and treat infectious disease. We have an industry-leading pipeline and offer a unique and strong collaborative network as part of the AstraZeneca family. Currently, we are seeking a Scientist with a strong protein biochemistry background to progress early bioprocess activities for preclinical vaccine pipeline programs. This will be a key member of the team developing next-generation vaccines. The position requires both the ability to work collaboratively with a team and independently progress laboratory bench work for driving projects forward. AstraZeneca has a dynamic environment that fosters collaboration and innovation as we look to attract and develop top talent.

Requirements

• Bachelor's or master's degree in Biochemistry, Bioengineering, Molecular Biology or related scientific field with 4+ years of experience is – MD 2+ YOE.
• Knowledge of protein analytical characterization techniques including BLI, SEC, DLS, HPLC, DSF.
• Strong verbal and written communication and organizational skills.
• Demonstrated troubleshooting ability and multi-tasking capabilities.
• Ability to work collaboratively with direction from project scientists.

Nice To Haves

• Recombinant protein expression (mammalian and/or bacterial) is preferred.
• Practical knowledge of recombinant protein purification using AKTA systems is preferred.
• Demonstrated ability to utilize AI-based tools in support of development projects is preferred.

Responsibilities

• Collaboratively designs and executes studies for screening and optimization of computationally designed preclinical vaccine candidates, then carrying those candidates through lab-scale purification, characterization, formulation, and stability testing.
• Troubleshoots issues with processes, methods and/or results.
• Designs, develops and implements analytical assays (BLI, SEC-MALS, DLS, DSF, HPLC, UHPLC).
• Documents detailed findings in reports and memos suitable to support regulatory document submission and tech transfer to clinical process development teams.
• Executes activities within a matrix team.
• Communicates experimental findings in written and oral format to project teams.
• Makes detailed observations, interprets data and organizes results and recommendations into reports and presentations.
• Maintains complete and accurate laboratory notebooks.
• Collaborates with internal teams and external vendors on development projects.
• Operates and oversees the maintenance of lab instruments.

Benefits

• qualified retirement program [401(k) plan]
• paid vacation and holidays
• paid leaves
• health benefits including medical, prescription drug, dental, and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Associate degree