Scientist, Drug Product Development
About The Position
NewLimit is seeking a Scientist to join our Delivery Sciences team. In this role, you will development formulations, purification processes, and characterization methods for lipid nanoparticle (LNP) drug products. NewLimit’s reprogramming medicines rely upon these LNP chemistries to carry reprogramming payloads to target cells and tissues throughout the body. The ideal candidate possesses a deep technical understanding of LNP assembly via various mixing methods, expertise in downstream purification, and hands-on experience with advanced analytical characterization techniques.
Requirements
- Ph.D. in Biomedical Engineering, Chemical Biology, Pharmaceutical Sciences, or a related discipline or equivalent industry experience
- Experience formulating LNPs with diverse lipid components for nucleic acid delivery
- Experience with purification techniques, including dialysis, Tangential Flow Filtration (TFF), ultracentrifugation, and sterile filtration.
- Proficiency in LNP analysis using dynamic or multi-angle light scatting, liquid chromatography, and standard molecular biology assays (ELISA, qPCR, spectroscopy).
Nice To Haves
- Experience contributing to drug product development at the preclinical or clinical stages.
- Background in extra-hepatic nucleic acid delivery.
- Experience with bioconjugation, surface modification, or targeted LNP formulation.
- Experience with data visualization and statistical analysis (R, Python)
Responsibilities
- Formulate, purify, and characterize LNPs for nucleic acid delivery
- Collaborate with the Epigenetic Editing and Product teams (Immunology, Metabolism, Vascular) to develop LNP-RNA reprogramming medicines.
- Develop and optimize LNP compositions to target new cell types for reprogramming.
- Interpret complex experimental data and perform statistical analyses to reach robust conclusions.
- Maintain rigorous and detailed records of experimental protocols and results in an Electronic Laboratory Notebook (ELN).
Benefits
- Comprehensive Health, Dental, and Vision insurance.
- 401(k) plan with company match.
- Paid parental leave.
- Industry-leading PTO: 20 days per year plus holidays.
- On-site meals and snacks.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
