Scientist, Downstream Process Development
About The Position
The Scientist position will be part of the Biologics Downstream Development department in Devens, MA that is responsible for early and late stage process development of BMS' growing biologics pipeline. The candidate will be responsible for developing efficient, robust, and scalable downstream purification processes — including chromatography and filtration unit operations — for therapeutic biologics. The candidate will be working in a dynamic and collaborative team environment with opportunities to lead development and matrix teams, while enhancing our ever-growing biologics portfolio.
Requirements
- PhD in Biotechnology, Protein Chemistry, Biochemistry or Chemical/Biochemical Engineering, with 0-2 years, or MS with 2-4 years, or BS with 5-7 years of relevant industrial and/or academic experience preferred.
- Hands-on experience with downstream bioprocessing unit operations, including chromatography (e.g., affinity, ion exchange, HIC) OR membrane-based separations (e.g., UF/DF, depth filtration), is required.
- Knowledge of protein purification, protein stability, and demonstrated experimental skills for laboratory work are required.
- Critical qualities include a high degree of initiative, good verbal and written communication skills, strong scientific skills and attention to detail, and the ability to work collaboratively in a team environment.
Nice To Haves
- Knowledge of protein characterization and analytical techniques is preferred.
- Knowledge of statistical experimental design and data analysis is preferred.
Responsibilities
- Develop and implement scalable purification processes for biologics drugs to meet established timelines.
- Design, execute and perform data analysis for downstream process development laboratory studies, including protein A affinity, ion exchange, hydrophobic interaction, and mixed-mode chromatography, as well as ultrafiltration/diafiltration (UF/DF), membrane filtration and depth filtration processes.
- Organize and interpret results, present to matrix team and management.
- Support process scale-up and tech transfer activities in pilot plant and clinical manufacturing sites.
- Support clinical manufacturing by reviewing documents and/or using technical expertise to ensure successful manufacturing campaigns.
- Author electronic notebook records, process descriptions, process development reports, and other documentation/technical reports for progression of assets and/or support of regulatory filings.
Benefits
- Medical, pharmacy, dental, and vision care.
- BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
- 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
- Flexible time off (unlimited, with manager approval)
- 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
- 160 hours annual paid vacation for new hires with manager approval
- 11 national holidays, and 3 optional holidays
- Unlimited paid sick time
- up to 2 paid volunteer days per year
- summer hours flexibility
- leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs
- an annual Global Shutdown between Christmas and New Years Day.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
