Scientist, CMC Analytical

City Therapeutics•Cambridge, MA

1d•$117,333 - $132,667

About The Position

City Therapeutics is seeking a passionate Scientist, CMC Analytical to join our growing team. You will lead method development, qualification, and transfer to support internal labs and external partners. The role is hands-on and highly cross-functional, partnering with CROs/CMOs to define impurity profiles and deliver comprehensive characterization of oligonucleotide drug substances, drug products, and process intermediates (e.g., siRNA and conjugates). You will report to the Director, CMC Analytical and contribute directly to City’s next-generation siRNA programs.

Requirements

Ph.D. in Analytical Chemistry or related field with 3+ years relevant industry experience; M.S. with 7+ years; or B.S. with 10+ years.
Strong AX-HPLC and HPLC–MS technical background with hands-on oligonucleotide characterization experience.
Demonstrated skills in handling, analyzing, and characterizing oligonucleotides and related organic molecules.
Familiarity with cGxP expectations, analytical data systems, and data integrity principles.
Meticulous documentation, strong problem-solving, and the ability to operate with minimal supervision.
Excellent communication, organization, and teamwork skills; comfortable in a fast-paced, multi-project environment with shifting priorities.

Nice To Haves

Knowledge of CMC regulatory requirements (e.g., IND/IMPD) is a plus.

Responsibilities

Lead method development, verification/qualification, validation (as needed), and transfer for existing and new programs.
Develop and implement analytical technology such as HPLC-MS methods for impurity characterizations of oligonucleotides
Conduct exploratory stability studies for raw materials, intermediates, DS, and DP; interpret trends and recommend actions.
Generate high-quality data; analyze, interpret, and communicate results;
Write CMC source documents such as, but not limited to, analytical methods, development reports, qualification/validation protocols and reports
Operate, calibrate, maintain, and troubleshoot analytical instrumentation; ensure adherence to data integrity and safety practices.