Scientist - Cardiometabolic Disorders

Amgen • Thousand Oaks, CA

1d

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Requirements

• Doctorate degree OR Master’s degree and 2 years of experience in Cardiovascular research or related discipline OR Bachelor’s degree and 4 years of experience in Cardiovascular research or related discipline

Nice To Haves

• A PhD in a relevant field with 0-2 years of experience.
• A MS in a relevant field with 5+ years of experience.
• Ideal candidates should have broad experience working with models of cardiometabolic disease, both in vitro and in vivo.
• Ability to perform in vitro assays to dissect the mechanism of action of therapeutic molecules in cardiac myocytes, fibroblasts, adipocytes, endothelial cells, and other relevant cardiometabolic cell types.
• Ideal candidates should have in vitro experience with cultured cell lines, siRNA transfection techniques, western blotting, quantitative PCR techniques, RNA/DNA isolation, laboratory automation, high content imaging technology, and fluorescence microscopy.
• Demonstrated excellence working in a team environment and possessing good laboratory documentation skills.

Responsibilities

• Work collaboratively with a team of experts to conduct laboratory experiments to generate robust data supporting the preclinical validation of new therapeutic targets.
• Independently design, execute, and interpret in vitro and ex vivo experiments, including troubleshooting, optimization of assays, data collection, interpretation, biostatistical analysis, and presentation.
• The scope of work will include testing and developing cell lines, conducting gene expression and protein abundance assays, establishing functional assays based on phosphorylation, oligomerization events, or other readouts using high-content imaging or medium throughput plate-based techniques used to support both small and large molecule drug development programs.
• Participation in cross-functional drug development teams as a key intellectual and technical contributor.
• The candidate is expected to be well-versed in the pathophysiology of Obesity and Cardiometabolic Diseases and to be continuously aware of scientific developments in this disease area, with emphasis on preclinical research methodologies and models.
• Present research discoveries to Amgen colleagues and scientific meetings (oral/poster presentations and publish scientific papers in peer-reviewed journals).
• Function optimally in a team based/collaborative environment as part of a highly integrated team, possess excellent organizational, verbal, and written communication skills and demonstrate ability to produce reliable and reproducible results.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior