Scientist – Biotechnology Discovery Research

Lilly • Indianapolis, IN

2d • $65,250 - $169,400 • Onsite

About The Position

Eli Lilly’s Biotechnology Discovery Research (BioTDR) organization has a track record of discovering, optimizing, and delivering novel biotherapeutic medicines to the clinic for the treatment of unmet medical needs in diabetes, oncology, immunology, and neuroscience. This position is within the BioTDR Lead Optimization Group, and we seek a motivated scientist to join our team. The successful candidate will drive innovation within the Lead Optimization Group and work across the discovery and development interface to deliver Lilly’s early phase portfolio. Are you eager to drive innovation in a fast-paced, collaborative environment to develop life-changing medicines for patients? Our commitment to our employees, patients, and communities is unmatched, and we want you to be a part of our team.

Requirements

• Bachelor’s or Master’s degree in Analytical Chemistry, Biochemistry, Chemistry, or a related scientific field.
• Minimum of 0-2 years of academic, research institute, or industry experience.
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization and visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

Nice To Haves

• Working knowledge of the large-molecule drug discovery and development process, including developability assessment.
• Proficiency with various mass spectrometry platforms (e.g., Orbitrap, Q-TOF) and diverse software for data processing and analysis (e.g., Genedata Expressionist).
• Experience with automated high-throughput liquid handling systems for automated sample preparation.
• Experience working with biological samples (e.g., serum, tissue).
• Collaborate with cross-functional teams, including protein engineers, chemists, and biologists, to support lead selection and optimization efforts through advanced analytical characterization.
• Strong verbal and written communication skills, including the ability to share learnings across team boundaries.
• Excellent time management and organizational skills with the ability to adapt to changing priorities and deadlines and thrive in ambiguity.
• Experience with note booking and data analytics using Benchling.
• Promote a culture of safety and inclusion in the workplace, including coaching and mentoring peers and other scientists.
• Experience with chromatographic (LC, GC, IC) method development or validation in pharmaceutical, chemical, or a regulated industry setting.

Responsibilities

• Deliver LC-mass spectrometry-based data for the characterization of a diverse and growing large-molecule portfolio, including monoclonal antibodies, bispecific antibodies, fusion proteins, antibody-drug conjugates, peptides, oligonucleotides, viral (e.g. AAV, lentivirus) and non-viral (e.g. LNP, liposome) genetic medicines, etc.
• Leverage extensive knowledge of and experience with a broad range of characterization methods to inform developability assessment and lead optimization (e.g., intact mass analysis, identification of post-translational modifications, profiling molecule assembly and structural variants including disulfide mapping, identifying glycosylation patterns, etc.)

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Associate degree