Scientist, Bioanalytics

Vir Biotechnology•San Francisco, CA

2d•$116,000 - $146,000•Hybrid

About The Position

Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies. Vir Biotechnology has exclusive rights to the universal PRO-XTEN® masking platform for oncology and infectious disease. PRO-XTEN® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company. We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best. THE OPPORTUNITY Vir Biotechnology is seeking a detail-oriented, highly motivated Bioanalytical Scientist to join our Translational Development team. In this role, you will develop and implement bioanalytical methods to support large-molecule programs at both preclinical and clinical stages. Responsibilities include designing and executing immunochemistry assays (e.g., ELISA, MSD, anti-drug antibody assays) and preparing samples for LC-MS/MS analysis. You will contribute to immunoassay development across multiple programs and analyze preclinical samples for drug concentrations and anti-drug antibodies. This description outlines the primary responsibilities and requirements but is not exhaustive; additional related duties may be assigned as needed. This position is based at our San Francisco headquarters, with an expectation of at least 4 days per week on site.

Requirements

PhD with 1+ years, MS with 6+ years, or BS with 8+ years of relevant industry experience.
Experience that combines hands-on laboratory work with project oversight; prior experience managing CROs for clinical and nonclinical assay development/validation is a plus.
Demonstrated understanding of GLP/GCP principles as they pertain to sample handling and storage, bioanalytical assay development, sample analysis, and laboratory operations.
Strong technical expertise with platforms used to characterize large-molecule therapeutics, including assays with complex handling and preparation (e.g., enzymatic, ligand-binding, cell-based assays, and LC-MS/MS assays) across a range of biological matrices (e.g., serum, plasma).
Familiarity with PK/PD concepts and their application to assay design, selection, and range determination.

Nice To Haves

Prior work in GCP/GLP/GMP environments is advantageous but not required.
Prior work utilizing LC/MS/MS is advantageous but not required

Responsibilities

Develop and optimize bioanalytical methods to support large-molecule preclinical and clinical candidates, providing bioanalytical input across research and development stages.
Plan and coordinate method development and sample analysis activities in alignment with program and development timelines.
Troubleshoot and evaluate complex bioanalytical methods to identify and implement robust solutions.
Prepare and characterize assay reagents using standard biochemical techniques (e.g., protein conjugation, concentration determination, UV/Vis spectrophotometry).
Maintain thorough and timely documentation in electronic lab notebooks; compile, analyze, and interpret data.
Present experimental plans and results in group and cross-functional settings to communicate assay development progress.
Perform routine instrument maintenance, calibrations, and performance checks as needed.
Collaborate closely with other assay development team members to achieve project and departmental goals.