Scientist, Bioanalytical

MSD•South San Francisco, CA

4d•$89,000 - $140,100•Onsite

About The Position

The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) organization at our company's Research Laboratories is seeking a highly motivated and collaborative scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) group in South San Francisco (SSF). The Scientist will provide laboratory support for the multi-disciplinary drug discovery effort in SSF, with a focus on supporting preclinical development of therapeutics of various modalities through integrated understanding of drug disposition and pharmacology. The scientist will work within teams of highly collaborative scientists to contribute to characterization of novel drug candidates in a range of therapeutic areas. The scientist will be responsible for planning and conducting in vitro/ex vivo studies to the DMPK properties of biologics, conjugates and other modalities. The ideal candidate will work with the team and interpret data, integrate, and clearly present results to help the team inform pipeline decisions. The candidate will also contribute to scientific initiatives for further understanding of ADME and discovery bioanalytical science. The successful candidate should have knowledge and hands-on experience with biologics bioanalytical, cell-based assays and handling biomatrices. The scientist must be highly motivated, able to work collaboratively in a fast-paced environment and have excellent scientific, interpersonal, and communication skills.

Requirements

Bachelor's with (3+ years) or Master's in analytical science, biology, biochemistry, pharmaceutical sciences, chemistry, pharmacology, biochemical engineering, biophysics or related discipline and relevant experience.
Demonstrated experience with mammalian cell culture and performing cell-based assays.
Demonstrated experience in biologics bioanalytical experimentation, such as ligand binding assays, FACS, etc.
Bioanalysis
Bioanalytical Methods
Bioanalytical Techniques
Cell-Based Assays
Cell Cultures
Ligand Binding
Ligand Binding Assay
Mammalian Cell Culture
Pharmacokinetics

Nice To Haves

Previous experience in a research environment or/and in drug discovery and development.
Demonstrated experience with protein characterization using biochemical or biophysical techniques.
Previous experience developing or performing assays with automated system.
General knowledge of PK, ADME and/or drug discovery concepts is a plus not a must.
Demonstrated creativity and innovation via a publication/presentation record.
Proficient in using data analysis software, such as Graphpad, Excel, etc.
Experience in using electronic notebooks is desirable.
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are place, introductions are position specific. Please, no phone calls or emails.

Responsibilities

Provide laboratory support for the multi-disciplinary drug discovery effort in SSF, with a focus on supporting preclinical development of therapeutics of various modalities through integrated understanding of drug disposition and pharmacology.
Work within teams of highly collaborative scientists to contribute to characterization of novel drug candidates in a range of therapeutic areas.
Plan and conduct in vitro/ex vivo studies to the DMPK properties of biologics, conjugates and other modalities.
Interpret data, integrate, and clearly present results to help the team inform pipeline decisions.
Contribute to scientific initiatives for further understanding of ADME and discovery bioanalytical science.