Scientist, Analytical Development (Contract)

Allogene Therapeutics • South San Francisco, CA

1d • Onsite

About The Position

About Allogene: Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T) products for cancer and autoimmune disease. Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell product candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. About the role: Allogene’s Process and Product Development organization is building a world class team that is focused on delivering potentially lifesaving therapies to patients. We are seeking a highly motivated individual to join us as a Scientist, Analytical Development in a contract capacity. This role will be a hands-on role reporting to the Associate Director, Attribute Science and PPD. The position is a lab-based, onsite role based at Allogene’s headquarters in South San Francisco. This is a 1-year contract opportunity with the possibility of extension or contract-to-hire.

Requirements

• Self-motivated, detail-orientated, and eager to be part of a positive work environment with other researchers to develop allogeneic CAR T cell therapies targeting cancer
• Bachelor’s or Master’s degree with at least 3 years of relevant cell biology, immunology or biochemistry experience
• Cell culture techniques, cell banking and cell bases assay development experience
• At least 2 years of hands-on experience with nucleic acid isolations, quantification, and NGS assay workflows (bulk RNA-seq, single-cell omics, WGS, etc.)
• Specific experience with quantitative analytical techniques including qPCR, ddPCR, ELISA and fluorescence-based enzymatic assays
• Excellent organizational skills and an ability to prioritize effectively to deliver results within established timelines
• Ability to work independently and as part of a team, strong interpersonal skills including relationship building, conflict resolution, and verbal and written communication are essential in this collaborative work environment
• Candidates must be authorized to work in the U.S.

Nice To Haves

• Experience with cell therapy products is a plus
• Working knowledge of Quality control and GMP requirements, and BLA enabling activities is a plus

Responsibilities

• Participate in method execution and qualification in support of analytical method development & performance, drug product characterization and product release
• Primarily optimize and help qualify analytical test methods involving qPCR, ddPCR and other molecular biology assays, as well as support the development of cell-based and/or immunoassays
• Actively contribute to the execution of NGS-based pipelines for the characterization of CAR T manufacturing processes and products
• Work with CROs to identify and implement process improvements focused on quality, turnaround time, and cost
• Document laboratory procedures and experimental data in ELN with great attention to detail
• Maintain, calibrate, and operate analytical instruments
• Work with a cross-functional team to advance the development of Allogene’s CAR T programs
• Other duties as assigned

What This Job Offers

• Career Level: Mid Level
• Number of Employees: 101-250 employees