Scientist, Analytical Development and Quality Control

Flagship Pioneering, Inc.•Cambridge, MA

2d•$96,000 - $126,500

About The Position

We are seeking a highly motivated and skilled candidate for a role of Scientist I on the Analytical Development and Quality Control team. This candidate will contribute to: building efficient system for testing samples and delivering the data; method development, optimization and qualification to support characterization of novel nucleic acid therapeutics and LNP delivery vehicles. We are looking for an individual who enjoys hands-on laboratory benchwork as well as mentoring other team members and brings scientific rigor and intellectual curiosity to their role. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment as part of a highly collaborative and rapidly growing team.

Requirements

Degree in Chemistry, Biochemical Engineering, Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or related field.
B.S. degree with 10+ years, M.S. degree with 8+ years, Ph.D. with 0+ years of relevant industry experience
Technical expertise in HPLC separations and plate-based assays (e.g. ELISA, qPCR/dPCR, residual protein)
Proven ability to independently design, execute, and troubleshoot complex experiments
Strong communication and organization skills; good working knowledge of Benchling, MS Office, JMP, GraphPad, Empower, Chromeleon
Demonstrates attention to detail, meticulous record keeping and personal organization
Ability to analyze, compile, and present experimental data in oral presentations as well as in technical reports
Strong technical writing skills to support method SOPs, protocols, and reports

Nice To Haves

Prior hands-on experience working on HPLC methods applied to mRNA/DNA cargo and nanoparticle delivery vehicles (e.g. LNPs or liposomes) is highly desired
Experience mentoring, training, or providing technical guidance to junior staff is desired

Responsibilities

Work with the team to drive advancement of platform development and play a vital role in shaping our analytical capabilities.
Step into benchwork to execute platform goals with tenacity and agility.
Setup, maintain, and optimize a system for efficient sample testing and data delivery
Ensure robustness of generated data through tracking historical data
Conduct method development to support nucleic acid cargo and LNP product release, stability, and characterization
Lead experimental studies to optimize specificity, sensitivity, precision, accuracy, and/or linearity of analytical methods
Analyze, troubleshoot, and communicate experimental findings clearly and succinctly in oral, written, and visual formats
Troubleshoot assay development and instrument operation issues as they arise
Run assays on samples generated during platform development studies
Maintain inventory of nucleic acid cargo and deliver materials supporting development and formulation activities
Document lab activities in detailed protocols and reports in an electronic lab notebook (Benchling)
Compose and revise SOPs and train team members on new assays
Present experimental results and updates to internal teams
Assist with general laboratory tasks as needed to ensure efficient operations
Work independently and collaboratively in a multidisciplinary team environment.