Scientist, ADC Oncology Discovery Biology

Bristol Myers Squibb•Cambridge Crossing, VA

8d•$129,640 - $157,096•Onsite

About The Position

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities. We are seeking an experienced individual with biologics drug discovery expertise to join the Discovery Biology team within the Oncology Thematic Research Center at Bristol-Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, interactive, and creative scientist and with the ability to work across a highly matrixed organization to advance programs from target validation to lead optimization, selection of drug candidate and IND-enabling biology related activities. This individual will be dedicated to designing and executing experimental studies related to the decisional progress of our programs from early stages all the way through IND filling. The candidate will be involved in executing biology bench studies that will advance the understanding of mechanism of action as well as developing several screening funnel assays that will enable compound triaging and identification of potential drug candidate. In addition, the individual will work closely with the informatics and predictive science, translational research, and lead optimization teams to design/execute work related to patient stratification, identification of appropriate in vitro PD markers and assay development/transfer for miniaturization.

Requirements

Bachelor’s Degree and 5+ years of academic and / or industry experience
Master’s Degree and 3+ years of academic and / or industry experience
Ph.D. or equivalent advanced degree in the Life Sciences with no experience necessary

Nice To Haves

Bachelor’s/Master’s Degree and 1-2 years relevant industry experience.
Experience in oncology and immuno-oncology biologics drug discovery (antibody-drug-conjugates preferred).
Proficient with expression modulation tools e.g. CRISPRs, shRNAs, siRNAs.
Extensive knowledge of flow cytometry, Incucyte and high content imaging platforms
Experienced in the design, development and optimization of high-throughput cell-based assays for antibody screening and ADC activity
Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work.
Ability to summarize and interpret scientific data in a clear, concise, and accurate manner.
Excellent oral and written communication skills. Ability to communicate well with peers and supervisors.
Strong problem-solving skills and understanding of relevant scientific principles.

Responsibilities

Uses current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates
Applies extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships
Designs and executes molecular and cellular studies.
Collaborates with rest of biology team members as well as other functional area leads e.g. pharmacology, DMPK, informatics and predictive science.
Presents data in lab meetings as well as full team project meetings.
Executes experiments independently, troubleshoot as needed, interpret, and discuss data.
Utilizes excellent communication and interpersonal skills.
Communicates via email, meetings, and reports.
Conducts experimental work independently, with accurate, detailed record-keeping.
Performs laboratory work related but not limited to tissue culture, qPCR, western blot, multi-parametric flow cytometry, immune cell culture using activation/expansion/exhaustion assays, proliferation and tumor killing assays, 2D/3D co-culture activity assays, ELISA, Luminex, processing of DNA/RNA/protein.

Benefits

Medical, pharmacy, dental, and vision care.
BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Paid Time Off
US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Unlimited paid sick time
up to 2 paid volunteer days per year
summer hours flexibility
leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs
an annual Global Shutdown between Christmas and New Years Day.