Scientist 3, Cell Therapy - T Cell Biology

Genentech • Daly City, CA

3d • $103,400 - $192,000

About The Position

The Cell Therapy department within Genentech Research and Early Development (gRED) is seeking a motivated scientist to help develop novel cell therapies for patients with intractable diseases. We are looking for a highly collaborative, detail-oriented scientist with deep expertise in T cell biology and a strong foundation in primary T cell culture, multiparameter flow cytometry and immune cell engineering. The successful candidate will bring scientific rigor, creativity and a resourceful approach to solving complex biological and technical problems. This individual will work across diverse scientific and functional teams to advance Genentech’s cell therapy pipeline. The position reports to a Principal Scientist and will contribute to the scientific direction, collaborative culture and continued growth of the Cell Therapy department.

Requirements

• PhD, MD, DVM or equivalent degree with at least 3 years of relevant experience
• Extensive hands-on experience with primary T cell isolation, activation, culture, expansion and phenotypic characterization.
• Deep knowledge of T cell biology, including development, differentiation, effector function, exhaustion, memory and survival.
• Advanced experience in multiparameter flow cytometry, including panel design, selection of appropriate controls, assay optimization, data analysis and biological interpretation.
• Experience engineering primary immune cells using viral and non-viral gene delivery methods.
• Experience developing and executing cell-based functional assays relevant to T cell biology or cell therapy.
• Demonstrated ability to design rigorous experiments, troubleshoot complex technical problems and interpret multidimensional datasets.
• A record of scientific, technical or process improvement contributions in a relevant field, demonstrated through publications, patents, regulatory submissions or meaningful contributions to therapeutic programs.
• Strong organizational and communication skills, including the ability to document, present and discuss results with multidisciplinary audiences.
• A collaborative mindset and demonstrated ability to advance shared objectives across project teams.
• A strong work ethic grounded in scientific curiosity, rigor, attention to detail and a commitment to high-quality research.

Nice To Haves

• Knowledge of human T cell development, lineage specification or thymic biology.
• Familiarity with high-dimensional or spectral flow cytometry and associated analysis tools.
• Experience developing CAR-T, TCR-T or other engineered T cell therapies.
• Knowledge of CAR design, vector biology, T cell manufacturing or critical quality attributes relevant to engineered T-cell products.
• Experience with CRISPR-based or other genome-engineering technologies in primary T cells.
• Experience culturing and engineering human induced pluripotent stem cells (iPSCs).
• Experience differentiating iPSCs or hematopoietic progenitors toward immune or T-cell lineages.
• Experience working within multidisciplinary cell therapy discovery or development teams.
• Familiarity with in vivo models of liquid and solid tumors

Responsibilities

• Culture and engineer primary T cells and other relevant cell types.
• Develop and apply multiparameter flow cytometry assays to characterize T cell identity, differentiation state, activation, function, and fitness.
• Evaluate engineered T cells using appropriate phenotypic and functional assays, including proliferation, cytokine production, cytotoxicity and persistence-related measurements.
• Analyze complex datasets, draw incisive conclusions and use results to guide subsequent experimental strategy.
• Collaborate effectively with research, translational, computational, process development and other partner groups across and outside gRED.
• Maintain comprehensive and accurate experimental records using electronic laboratory systems.
• Communicate findings clearly through written reports, data packages and presentations to project teams and other stakeholders.
• Contribute to scientific and strategic planning for the Cell Therapy department and Genentech’s broader cell therapy pipeline.

Benefits

• Relocation benefits are available for this posting.
• A discretionary annual bonus may be available based on individual and Company performance.
• The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree