Scientific Leader, In Vivo Pharmacology

GSK • Cambridge, MA

9d

About The Position

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together. Find out more: Our approach to R&D Position Overview: We are seeking a highly motivated Scientific Leader to join the In Vivo Pharmacology team at GSK. The individual will be involved in designing and executing PK/PD studies supporting the advancement of oligonucleotide therapeutics. The successful candidate will bring deep hands-on expertise in rodent and non-human primate (NHP) models, strong experimental design skills, and direct experience with molecular assays, including qPCR. The individual will be a highly organized professional who can manage multiple projects simultaneously while maintaining quality. This role demands equal parts of operational excellence and scientific expertise. The role will be a key contributor to preclinical development programs.

Requirements

• PhD in Pharmacology, Biology, Biochemistry, or a related scientific discipline, with minimum 4+ years of relevant industry experience.
• Three or more years of experience in in vivo PK/PD study design and execution in rodent and non-human primate models.
• Two or more years of experience working with oligonucleotide therapeutics in a preclinical setting is required.
• Three or more years of experience independently designing studies, troubleshoot complex experimental challenges, and delivering high-quality data.
• Three or more years of experience conducting in vivo techniques, including dosing, tissue collection, and related procedures, is required.

Nice To Haves

• Experience working in a pharmaceutical or biotechnology research environment.
• Experience in working and managing CROs
• Hands-on experience with qPCR assays, including assay development, optimization, and data analysis of in vivo samples.
• Track record of delivering data for regulatory submissions or IND-enabling packages.
• Excellent written and verbal communication skills, with the ability to present data clearly to multidisciplinary teams.

Responsibilities

• Design, lead, and execute in vivo studies in rodent and non‑human primate (NHP) models to support target validation, lead optimization, and candidate selection.
• Manage and oversee in vivo studies conducted internally or with external CRO, including scope definition, protocol review, operational activities, data quality oversight, and scientific interpretation and communication of results.
• Ensure timely scheduling, execution, and delivery of in vivo studies in alignment with project plans, milestones, and decision points; proactively identify risks and implement mitigation strategies.
• Apply deep subject‑matter expertise in the biology, pharmacology, and delivery for evaluating oligonucleotide therapeutics or related modalities in preclinical models.
• Analyze, interpret data and communicate results clearly and objectively to key internal stakeholders.
• Collaborate cross-functionally with DMPK, non-clinical safety, chemistry, in vitro and project teams to ensure robust study design and data generation.
• Experience with hands‑on molecular biology assays, with a strong emphasis on qPCR, including assay development, optimization, execution, and data analysis from in vivo samples is strongly preferred.

Benefits

• In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role.
• Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree