RWE Director, Inhaled Portfolio

AstraZeneca • Wilmington, DE

13d • Hybrid

About The Position

This US-focused leadership role, based in Wilmington, DE, is responsible for shaping the clinical and economic value story for AstraZeneca's inhaled respiratory portfolio, including Airsupra and Breztri. The Director will translate this value into language understood by payers, health systems, and policymakers. Working collaboratively with Medical, Market Access, Field Medical, Commercial Insights, and Brand teams, the role involves designing and delivering evidence programs to address in-market gaps, inform strategy, and facilitate appropriate access and uptake. Key challenges include developing payer-ready evidence plans that anticipate policy shifts and identifying barriers to routine care use.

Requirements

• Advanced degree (PhD, PharmD, MD, or relevant Master’s) in Epidemiology, Health Services Research, Health Economics, Outcomes Research, Biostatistics, or a related field.
• 5+ years of relevant RWE experience in the pharmaceutical industry, managed care, academia, or consulting.
• Deep proficiency in observational study design, real-world data sources, and causal inference methods.
• Comprehensive, current understanding of the US healthcare system, including the evolving payer and policy landscape, quality measures, value-based care models, reimbursement dynamics, and guideline development.
• Strong written and verbal communication skills.
• Demonstrated publication record and ability to translate evidence for non-technical US stakeholders.
• Ability to work effectively across matrix teams (US and Global) with a high degree of autonomy.

Nice To Haves

• Demonstrated experience contributing to economic models, AMCP Dossiers, PVP decks, or contracting strategy inputs.
• Track record of building productive external partnerships with academic collaborators, registries, learning health systems, or data providers.
• Familiarity with applying AI/ML tools to RWE workflows; able to evaluate validity, limitations, and bias.
• Respiratory experience is strongly preferred, particularly in COPD or asthma and with inhaled/respiratory therapeutics.

Responsibilities

• Partner with US Medical, Market Access, Commercial Insights, and Brand teams to define and strengthen the clinical and economic value proposition for Airsupra and Breztri.
• Align evidence priorities to brand strategy and high-stakes US decision points to drive appropriate use and access.
• Lead facilitation of the Scientific Narrative and development of the Integrated Evidence Plan.
• Operationalize core messages across publications, congress presentations, payer dossiers, and field resources.
• Design, execute, and report observational studies, target trial emulations, registries, and pragmatic effectiveness research.
• Apply causal inference and robust bias mitigation to generate credible insights that influence medical and access strategies.
• Identify, evaluate, and secure fit-for-purpose claims, EMR, registry, and linked datasets.
• Champion representativeness and health equity in study design so findings reflect US clinical practice.
• Build and contribute to cost-effectiveness and budget impact models.
• Author AMCP Dossier sections and provide evidence inputs for PVP decks, formulary submissions, and contracting strategy.
• Translate RWE outputs into clear, actionable insights and tools for MSLs and Clinical Account Directors.
• Co-own the evidence-to-practice handoff with Implementation Science counterparts.
• Cultivate collaborations with academic investigators, learning health systems, real-world data providers, patient advocacy groups, and relevant registries or quality-measure bodies.
• Coordinate with global evidence and health economics counterparts to align methods and assets.
• Apply AI/ML tools in literature review, automated data quality checks, and signal detection with human-in-the-loop oversight.
• Document methods and lead peer learning to strengthen team capability.
• Adhere to research governance processes, including protocol review and scientific committee approvals.
• Ensure compliance with HIPAA, GCP, and internal SOPs.
• Contribute to internal methods development and peer review.

Benefits

• Science and strategy meet to deliver real impact for patients.
• Work with diverse experts to build ecosystem solutions that reach beyond our walls.
• Payer-ready evidence and quality measures.
• Practice interventions that change care.
• Move with urgency and clarity.
• Value kindness alongside ambition.
• Bring unexpected teams together to accelerate ideas from pilot to scale.
• Evidence will inform decisions across health systems and payers.
• Shape the next wave of respiratory innovation.

What This Job Offers

• Job Type: Full-time
• Career Level: Director