Research Technician-Dr. Cristancho's Lab
About The Position
This entry-level research technical role participates in planned research projects by performing research protocols, experimental procedures, and other laboratory tasks under direct supervision. The Cristancho lab is interested in understanding the epigenetic mechanisms driving long-term neurodevelopmental disabilities from acquired prenatal and perinatal brain injury. Their goal is to develop novel therapeutic interventions that can be applied throughout the lifespan to improve outcomes for children and their families. The lab has been phenotyping models of acquired brain injury through a comprehensive battery of behavioral tests and using advanced molecular biology techniques like single-nucleus RNA and ATAC-sequencing to understand the molecular pathways possibly underlying lasting deficits. They now seek to perform mechanistic studies to explore these pathways using histopathological techniques (IHC, IF), genetic manipulations (viral vectors, genetic models), proteomics, chromatin immunoprecipitation, high-throughput sequencing, and cell culture. This role will involve working with the PI and lab members to develop and troubleshoot new techniques in molecular neuroscience, imaging, and behavior. It will also involve organizing the lab, ordering and maintaining stock supplies/reagents, caring for lab equipment, and ensuring compliance with safety and institutional regulations. Specific responsibilities include managing the mouse colony, writing/amending IACUC protocols, coordinating and performing behavior studies, and performing and teaching animal exposures and surgeries. Development of IRB protocols for translational studies and tracking of ordering and spending are also part of the role.
Requirements
- At least one (1) year of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research laboratory experience Required
Nice To Haves
- Associate's Degree Preferred
- Bachelor's Degree Preferred
- At least two (2) years of related classroom experience or successful completion of a technical training program (eg. Wistar, WPSI) and research laboratory experience Preferred
- Cell Culture experience is preferred, specifically with primary neuronal and iPSC differentiation.
Responsibilities
- Independently performs advanced, complex research procedures on experimental samples
- Formulates and performs complex lab experiments and analyzes reports, including interpretation of methodologies
- Performs advanced calculations and maintains appropriate log and lab notebooks
- Plans and modifies research protocols and procedures with minimal direction from the principal investigator or supervisor
- Assists in the development & troubleshooting of new techniques and ideas
- Prepares laboratory reagents, monitors, and maintains laboratory inventory
- Supervises, trains, and mentors junior and new staff members
- Determines work assignments, schedules, and laboratory priorities
- Presents & discusses work at weekly lab meetings
- Assists in writing of grants, journal articles, poster and oral presentations
- Working with PI and lab members to develop and troubleshoot new techniques in molecular neuroscience, imaging, and behavior.
- Working with lab post-doctorate fellows, graduate students, research technicians, and undergraduate students to organize the lab, order and maintain stock supplies/reagents, care for lab equipment, and ensure compliance with safety and institutional regulations.
- Managing mouse colony with other lab members, writing/amending IACUC protocols, ensuring lab compliance, coordinating and performing behavior studies, performing and teaching animal exposures and surgeries.
- Development of IRB protocols for translational studies.
- Tracking of ordering and spending.
- Performs routine tests / experiments under the direction of principal investigator, supervisor or other designee
- Performs research procedures on experimental samples as directed
- Records and checks experiments/ results for completeness and accuracy
- Performs calculations and maintains appropriate log and lab notebooks
- Performs tasks that require familiarity with fundamental techniques and lab equipment
- May assist with planning specific research protocols and procedures
- Maintains office, lab area, solutions, reagents, supplies and equipment, disposes of specimens, media and other materials (using appropriate procedures)
- Assists in care and maintenance of lab equipment
- May coordinate schedules of tests and procedures
- Attends courses, seminars, and lab meetings to expand knowledge of research and laboratory techniques
- Records results, organizes data and maintains lab notebook in an organized manner
- Compiles and helps analyze data, prepares charts, graphs, and results of studies as directed
- Conducts literary searches as directed
Benefits
- Annual influenza vaccine
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
High school or GED
