Research Technician II
About The Position
The Department of Microbiology and Immunology is seeking a Research Technician II. The Dibra Lab studies immune evasion in immunotherapy-resistant cancers, with a focus on how TP53 alterations in breast and liver tumors disrupt immune surveillance and promote tumor persistence. A central strength of the lab is the development and use of novel, genetically engineered mouse models generated in-house, enabling us to interrogate tumor–immune interactions in physiologically relevant settings. We integrate these models with cutting-edge single-cell, spatial, and immunopeptidomic approaches to define how oncogenic p53 reshapes the tumor–immune microenvironment and drives resistance to T cell–based therapies. Our goal is to translate these mechanistic insights into rational, immune-based combination strategies for p53-mutant cancers.
Requirements
- Bachelor's degree in a related field and two (2) years of relevant experience or an equivalent combination of education and experience.
- Demonstrated strength in mouse husbandry and in vivo experimentation.
- Strong foundation in genetics and immune biology.
- Computational proficiency for data analysis.
- Capable of working across experimental and analytical domains.
- Show initiative, work efficiently with minimal supervision, and demonstrate the ability to adopt and implement new technologies quickly.
- Microsoft Office Suite – intermediate to advanced.
- Organized Use of Microsoft Word and Excel.
- Proficient in use of computers.
- Sterile technique/cell culture experience.
Nice To Haves
- Five (5) or more years of laboratory experience.
- Prior experience with immunology.
- Strong ability in complex animal work.
- Genetics/ immunological/ and/or computation background strongly preferred.
- PhD degree preferred.
Responsibilities
- Independently execute in vivo and in vitro experiments.
- Analyze and interpret data.
- Generate publication-quality figures.
- Maintain mouse colonies and associated databases.
- Working with murine cancer models.
- Performing cell isolation and immune cell handling.
- Applying molecular and cellular techniques such as genotyping, immunohistochemistry, real-time PCR, Western blotting, and tissue culture.
- Conduct experiments including cell separation, experiments requiring molecular and cellular as well as sterile techniques, or flow cytometry, immunohistochemistry, RNA and protein.
- Complex animal management tasks (e.g. mouse colony maintenance, breeding activities, IP and IV injections, animal euthanasia, mouse genotyping, organ procurement for analysis).
- Conduct experiments involving cancer mouse models.
- Collate and analyze experimental data in a timely manner.
- Make graphics maintain databases.
- Perform various in vitro tasks and assays (e.g. cell culture based, flow cytometry, sample preparation for spatial analysis and microbiome analysis) from cell culture, mouse tissue, and human (patient) tissue.
- Prepare materials and equipment necessary for laboratory tests.
- Perform general lab duties as assigned.
Benefits
- Compensation will be commensurate to candidate experience.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
