Research Specialist- School of Medicine, Hematology
About The Position
The Bhatt Laboratory in the Department of Hematology and Medical Oncology at Emory University School of Medicine is seeking a highly motivated Bioinformatician to join our dynamic research team. The successful candidate will work on high-impact translational research projects that bridge computational analysis with functional biology to identify novel therapeutic strategies for patients with blood cancers. The lab has established a strong track record of high-impact publications and has received prestigious funding from organizations including the American Cancer Society, European Molecular Biology Organization, American Association for Cancer Research, American Society of Hematology, and The Leukemia & Lymphoma Society. Lab website: https://www.bhatt-lab.com
Requirements
- Bachelor's degree in a scientific field OR equivalent combination of experience, education, and training.
- Strong programming skills in R and/or Python
- Experience with next-generation sequencing data analysis tools and pipelines
- Proficiency in statistical analysis and data visualization
- Familiarity with high-performance computing environments and cluster job submission systems
- Experience with version control systems (Git/GitHub)
Nice To Haves
- Bachelor's degree in Bioinformatics, Computational Biology, Data Science, Computer Science, Statistics, or related field with experience in bioinformatics analysis of genomics data (RNA-seq, scRNA-seq, ATAC-seq, or similar)
Responsibilities
- Under general supervision, performs a variety of defined research and laboratory tests and experiments according to prescribed protocols and assigned schedules.
- Sets up experiments as prescribed by a principal investigator.
- May be required to participate in laboratory maintenance activities such as sterilization and cleaning of equipment, ordering of supplies, inventory and media preparation.
- Maintains records, files and logs of work performed in laboratory notebooks and computer databases.
- Compiles data and records results of studies for publications, grants and seminar presentations.
- Employees in this classification may be required to work with, take specific precautions against and/or be immunized against potentially hazardous agents.
- Performs related responsibilities as required by principal investigator.
- Analyze large-scale multi-omics datasets including bulk and single-cell RNA sequencing, ATAC-seq, DNA sequencing, proteomics, and metabolomics data from AML patient samples and preclinical models
- Perform differential gene expression analysis, pathway enrichment analysis, and network analysis to identify key regulators of therapy resistance
- Analyze clonal evolution and lineage tracing data to map resistance trajectories during AML treatment
- Integrate functional genomics data (CRISPR screens) with transcriptomic and epigenomic datasets to identify therapeutic vulnerabilities
- Develop machine learning models to predict therapeutic response based on multi-omics features
- Build predictive algorithms for patient stratification using dynamic BH3 profiling data and molecular profiles
- Apply dimensionality reduction techniques and clustering methods to identify AML subpopulations with distinct resistance mechanismsEducation and Experience
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Number of Employees
5,001-10,000 employees
