Research Scientist

University of Colorado•Aurora, CO

1d•Onsite

About The Position

A Research Scientist position is available in the School of Medicine Mass Spectrometry Proteomics Facility at the University of Colorado Anschutz Medical Campus. We are seeking a highly motivated individual to help solve challenging biomedical problems using state-of-the-art mass spectrometry techniques. Prospective candidates will join a productive team leveraging advanced bioanalytical methods to address complex questions in health and disease. Candidates must be self-motivated, detail oriented, have a strong aptitude for learning new areas of research, and be adept at managing multiple projects in parallel. The Research Scientist will have the opportunity to interact with a variety of researchers, both locally and nationally, and will support proteomics and informatics analysis for several funded projects aimed at improving patient outcomes. Ideal candidates have a Ph.D. in biological, chemical or computer sciences, with significant experience in mass spectrometry-based proteomics, bioinformatics, and wish to expand their training in multiple disciplines.

Requirements

Master’s degree in biology, molecular biology, chemistry, genetics or related field
Prior experience or background within an experimental or wet lab
Prior experience in mass spectrometry-based proteomics
Two (2) or more years’ experience preparing samples for LC-MS analysis.
Two (2) or more years’ experience with bench science and analytical instrumentation.
Experience with bioinformatics

Nice To Haves

PhD degree in biological sciences, computational disciplines, or a related field within the last three years.
Record of productivity supported by peer-reviewed publications in internationally recognized journals
Experience with Thermo and Bruker LC-MS platforms
Experience with FragPipe, PEAKS, Proteome Discoverer, Spectronaut and DIA-NN

Responsibilities

Prepare complex biological samples (tissues, plasma, cell cultures) and execute proteomics workflows spanning global proteomics, phosphoproteomics, ECM proteomics, targeted proteomics, and more.
Acquire, process, and analyze mass spectrometry datasets using established and emerging bioinformatics pipelines, including statistical evaluation and validation of results.
Assist in the development and optimization of analytical and sample preparation methodologies to advance facility capabilities.
Maintain and perform routine upkeep of mass spectrometry instrumentation and associated laboratory equipment, including reagent and buffer preparation.
Generate detailed reports and maintain comprehensive laboratory records, including experimental metadata and data management documentation.
Collaborate regularly with faculty, students, clinicians, and external investigators to discuss experimental design, data interpretation, and study outcomes.
Contribute to the preparation of manuscripts, presentations, and technical reports, and assist with laboratory operations including protocol development, supply management, and data storage systems.