Research Scientist/Engr 4
About The Position
The field of research for this position involves single particle cryo-electron microscopy and X-ray crystallization of viral glycoproteins, immunogen design, virology, biochemistry, and biophysics. The primary goal of the research project(s) is to develop vaccines and therapeutics targeting human pathogens. The role involves structure-based and machine-learning immunogen design for protein subunit and mRNA vaccines, characterization of protein antigenicity, performing structural studies using cryo-electron microscopy and X-ray crystallography, designing and executing virology assays, analyzing data to guide research strategy, leading projects, interacting with collaborators, writing manuscripts, and providing guidance to project staff, students, and postdocs.
Requirements
- Master's Degree in Biochemistry or related field
- Four years of experience in related field like: Cryo-electron microscopy, virology assays (pseudotyped virus generation, cellular entry and neutralization assays), protein expression in mammalian cells and purification
- Equivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration.
Nice To Haves
- Expertise in protein and vaccine design
- Experience in high throughput automation using Beckman Biomek
Responsibilities
- Structure-based and machine-learning immunogen design for protein subunit and mRNA vaccines based on viral surface glycoproteins (construct design, recombinant expression in mammalian cells, purification, and stability assays)
- Characterize protein antigenicity (binding assays using ELISAs, SPR and biolayer interferometry to evaluate binding kinetics and affinity of antibodies or designed proteins)
- Perform structural studies (high-throughput cryo-electron microscopy of subunit vaccines as well as of complexes between viral glycoproteins and monoclonal and polyclonal antibodies as well as X-ray crystallography)
- Design and execution of virology assays
- Analysis of the data to help determining the research strategy
- Lead projects and/or major project tasks
- Interactions with collaborators within our network and writing of manuscripts for publication
- Provide guidance and direction to project staff, students and postdocs
Benefits
- For information about benefits for this position, visit https://www.washington.edu/jobs/benefits-for-uw-staff/
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What This Job Offers
Job Type
Full-time
Career Level
Senior
