Research Fellow in Cilia Biology, Cardiac Development and Zebrafish Genetics, Yuan Lab, MGH Cardiovascular Research Center

Mass General Brigham • Boston, MA

7d • Onsite

About The Position

The laboratory of Dr. Shiaulou Yuan at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) is seeking highly motivated candidates for a full-time postdoctoral research fellow position. We are a multidisciplinary group of biologists, biophysicists, and microscopists who aim to understand how fluid flows and biophysical forces shape the developing heart and how these mechanisms underlie cardiac disease pathogenesis when gone awry. Specifically, we seek to illuminate how the cilium, a hair-like structure found on most cells in the human body, acts as an “antenna” to sense and translate extracellular signals into molecular processes that sculpt the early heart. The penultimate goal of our research is to advance our understanding of cardiac development and diseases by combining state-of-the-art approaches from developmental biology, cell biology, genetics, biophysics, and advanced microscopy in zebrafish animal models and human stem cells. This position offers excellent opportunities to work in a highly collaborative and multi-disciplinary biomedical atmosphere, interact with distinguished scientists, physicians and physician-scientists at MGH-Harvard, and become a valued member of a collegial and growing research team. As a member of Harvard University, Massachusetts General Hospital, Mass General Brigham, and the Boston scientific community, the candidate will be immersed in a rich environment for zebrafish genetics, cardiovascular biology, cilia signaling, molecular biology, and imaging technologies.

Requirements

• Strong background working with zebrafish
• PhD, MD, MD/PhD or equivalent doctoral degree in a relevant field
• Prior training in zebrafish husbandry and colony management
• Prior training in embryo micro-injection
• Prior training in embryo micro-dissection
• Prior training in confocal or light sheet microscopy
• Prior training in live cell imaging
• Prior training in quantitative image analysis
• Prior training in immunofluorescence
• Prior training in in situ hybridization
• Prior training in molecular cloning
• Prior training in CRISPR-Cas9 gene editing
• Prior training in recombinant protein techniques
• Prior training in human stem cell culture techniques
• Passion for developmental biology, cell biology, cardiovascular biology, and microscopy
• Ability to work independently and as part of a team
• Excellent written and verbal communication skills
• Strong work ethic and superb attention to details
• Exceptional technical and experimental skills

Nice To Haves

• Experience training and supervising junior scientists, technicians and/or students.

Responsibilities

• Conduct research in cilia biology, cardiac development, and zebrafish genetics.
• Combine state-of-the-art approaches from developmental biology, cell biology, genetics, biophysics, and advanced microscopy.
• Work with zebrafish animal models and human stem cells.
• Train and supervise junior scientists, technicians and/or students.

Benefits

• Opportunities to work in a highly collaborative and multi-disciplinary biomedical atmosphere
• Interact with distinguished scientists, physicians and physician-scientists at MGH-Harvard
• Become a valued member of a collegial and growing research team
• Immersed in a rich environment for zebrafish genetics, cardiovascular biology, cilia signaling, molecular biology, and imaging technologies

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree