Research Engineer I II/III (AI / Machine Learning)

Gladstone InstitutesSan Francisco, CA
Hybrid

About The Position

The Jain Lab develops new approaches to understand how oxygen, metabolism, and vitamins regulate physiology and disease. They combine CRISPR screens, multi-omics, imaging, computational biology, and animal models to answer fundamental biological questions and develop new therapies. They are seeking a highly motivated AI Research Engineer to help build an AI-native research laboratory. This role will develop AI systems that access scientific literature, laboratory datasets, electronic lab notebooks, Slack discussions, manuscripts, protocols, and experimental results in order to generate hypotheses, critique ideas, design experiments, and accelerate discovery. This is a unique opportunity to work at the intersection of frontier AI and experimental biology, helping define how AI transforms biomedical research.

Requirements

  • BS or MS in Computer Science, AI, Machine Learning, Computational Biology, Bioengineering, or a related quantitative discipline.
  • 0–2 years of research or industry experience (outstanding undergraduate applicants encouraged).
  • Strong Python programming skills.
  • Strong knowledge of best practices for AI-assisted coding with tools like Claude Code, Codex, OpenCode, etc.
  • Strong knowledge of agentic AI fundamentals such as MCP servers/tool calling loops, embeddings & vector databases, Skills & context engineering, and related technologies.
  • Experience building projects with LLMs and agentic AI frameworks such a Langchain/Langgraph, OpenAI/Gemini/Claude SDK, etc.
  • Experience with cloud infrastructure (GCP, AWS, Azure), Docker, Git, and modern software engineering practices.
  • Interest in biology and enthusiasm for learning molecular biology and biomedical research.
  • Excellent communication and collaboration skills.

Nice To Haves

  • Coursework or research experience in molecular biology, genetics, computational biology, or bioinformatics.
  • Experience with biological datasets (RNA-seq, CRISPR screens, imaging, proteomics, metabolomics).
  • Experience developing AI agents that interact with APIs, databases, or external tools.
  • GitHub, open-source contributions, or substantial personal AI projects.

Responsibilities

  • Design and build systems for ingesting literature, datasets, electronic lab notebooks, Slack discussions, meeting transcripts, code repositories, protocols, etc. into a "lab knowledge repository" (data layer) optimized for search & retrieval of information by AI agents.
  • Develop agentic AI systems that reason across the lab knowledge repository, and use external tools to perform multi-step scientific workflows tailored to the lab's focus and ways of working.
  • Build always-on AI agents that proactively review new papers, meetings transcripts, etc. and make connections, suggest hypotheses & experiments, identify flaws or gaps, and help with interpretation.
  • Collaborate closely with experimental scientists to rapidly prototype and deploy AI tools.
  • Evaluate new & emerging AI tools for biomedical research and incorporate state-of-the-art methods into the lab.

Benefits

  • Generous medical, dental, vision, retirement plan, paid vacation, commuter benefits, access to free shuttle transportation.
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