Research Associate (Contract to Hire) – In Vivo Biology

Lime Therapeutics • New York, NY

1d • $35 - $50 • Onsite

About The Position

Lime Therapeutics is seeking a highly motivated Research Associate – In Vivo Biology to join its growing biology team and advance oncology drug development programs. Lime Therapeutics is a venture-backed biotech startup developing therapies that target lipid-metabolic pathways in cancer, metabolic, and neurodegenerative diseases, and is advancing therapeutic concepts toward IND-enabling studies and clinical development.

The Research Associate will work closely with experienced scientists to execute preclinical studies, evaluate therapeutic candidates, and generate data that informs drug development decisions. This hands-on role is suited to an early-career scientist interested in experimental biology and developing technical skills in an early-stage biotech setting. The role is a six-month contract-to-hire position, with potential conversion to full-time based on performance and business needs.

The position is fully in person at Lime Therapeutics’ headquarters at the Ford Center Incubator at The Rockefeller University on Manhattan’s Upper East Side. It is an hourly role paying $35–$50 per hour, commensurate with skills and experience. The stated start date is January 2027.

Requirements

• BS or MS in Biology or a related field.
• Hands-on rodent in vivo experience and exposure to molecular assays in an academic, biotech, pharmaceutical, or CRO setting.
• Proficiency in mouse handling, restraint, and dosing.
• Working knowledge of IACUC protocols and animal welfare standards.
• Strong aseptic technique and experience maintaining cancer cell lines and preparing cells for in vivo implantation.
• Ability to follow protocols precisely and manage multiple concurrent studies.
• Self-starter who takes ownership and thrives in a high-accountability environment.
• Motivation to learn new techniques and develop skills as research programs advance.

Responsibilities

• Conduct preclinical oncology studies in relevant cancer models to evaluate the efficacy and tolerability of therapeutic candidates.
• Handle and restrain mice and administer compounds by oral gavage and intraperitoneal, subcutaneous, and intravenous injection.
• Collect and process tissues for molecular, biochemical, histological, and flow cytometry-based analyses.
• Establish and maintain mammalian cell cultures, including cancer cell lines, primary cells, and organoids, and support cell-based assays and molecular biology experiments.
• Maintain accurate experimental records, analyze study data using GraphPad Prism and Excel, and communicate results to the scientific team.
• Prepare experimental materials, maintain laboratory equipment and supplies, and comply with IACUC-approved protocols and laboratory safety standards.
• Collaborate in a fast-paced startup, adapt to changing research priorities, and support time-sensitive experiments, including occasional evening or weekend work as animal study schedules require.

Benefits

• Opportunity to contribute to the development of first-in-class therapeutics for patients with high unmet need.
• Work directly with company leadership and world-class advisors.
• Opportunity to build and eventually lead scientific teams as the company expands.
• Mission-driven culture characterized by high ownership, strategic focus, and fast execution.

What This Job Offers

• Career Level: Entry Level