Research Associate / Senior Research Associate, Analytical Development and QC
About The Position
Addition Therapeutics is seeking a motivated Research Associate / Senior Research Associate (Contract) to join our Analytical Development team and help advance the development of next-generation RNA therapeutics. In this role, you will perform analytical testing of plasmid DNA, RNA, and lipid nanoparticle (LNP) formulations while contributing to the development, optimization, qualification, and transfer of analytical methods that support process development and preclinical manufacturing. Working in a collaborative, fast-paced startup environment, you will partner closely with Process Development, Formulation, and CMC teams to generate high-quality analytical data that drives scientific decision-making and enables the development of RNA drug substances and LNP drug products.
Requirements
- Experience characterizing plasmid DNA, RNA, lipid nanoparticles, and/or related process impurities.
- Strong analytical, problem-solving, organizational, and technical communication skills.
- Ability to work independently and collaboratively in a fast-paced, team-oriented environment.
- BS or MS in Chemistry, Molecular Biology or a related scientific discipline with 2+ years of relevant industry experience in analytical development, QC, or biopharmaceutical laboratories.
Nice To Haves
- Hands-on experience with HPLC (CAD, UV, or MS), capillary electrophoresis, qPCR, ELISA, and/or plate-based biochemical assays.
- Experience with analytical method development, qualification, validation, or technology transfer.
- Experience working with RNA therapeutics, in vitro transcription (IVT), and/or lipid nanoparticle (LNP) drug products.
Responsibilities
- Perform routine QC testing and analytical characterization of plasmid DNA, RNA, and RNA-loaded LNPs.
- Develop, optimize, and execute analytical methods to assess RNA identity, purity, integrity, capping efficiency, poly(A) tail length, process impurities (e.g., residual plasmid DNA, proteins, dsRNA), and LNP physicochemical properties.
- Analyze, interpret, and document experimental data in electronic laboratory notebooks (ELNs), and communicate findings to cross-functional teams.
- Investigate analytical deviations, troubleshoot assays and instrumentation, and support technical investigations.
- Author and maintain SOPs, analytical methods, protocols, and technical reports.
- Support analytical method qualification, validation, and technology transfer activities.
- Maintain laboratory equipment, inventory, and an organized laboratory environment.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
