Research Associate in 3D Human Tissue Bioprinting for Modeling Neurodegenerative Disorders

University of British Columbia • Vancouver, BC

7d • Onsite

About The Position

The Post-Doctoral candidate will develop/design, implement and publish research studies related to the cellular processes associated with Alzheimer’s disease (AD) and frontotemporal dementia. Specifically, the position involves maintaining and advancing a robust protocol for 3D bioprinting of iPSC derived neurons, astrocytes, and microglia to study the pathophysiology of AD and FTD in a 3D environment. In addition, methods of research including but not limited to: human induced pluripotent stem cells (hiPSC), cerebral organoids, CRISPR gene editing, transfections, imaging techniques, electrophysiology and biochemical/molecular biology techniques. The candidate will have a strong teaching role for graduate, undergraduate and co-op students. The position requires a strong research background in neuroscience and neuroscience techniques including iPSCs generation, differentiation, and maintenance, tissue culture, and confocal imaging. The candidate must have a PhD, and at least 2 years of post-doctoral experience in advanced 3D bioprinting of hiPSC neurons using an extrusion-based bioprinter. The candidate must further have advanced knowledge of bioink preparations, including those based on collagen.

Requirements

• PhD in the field of neuroscience or related field
• At least 2 years of post-doctoral training in hiPSC 3D extrusion-based bioprinting
• Proven skills using hiPSCs studying the pathophysiology of neurodegenerative or other CNS disorders
• Strong analysis skills
• Ability to work professionally with colleagues, donors, and staff
• Compliance with approved procedures and ethics regulations

Nice To Haves

• Publications in the area are an asset

Responsibilities

• 3D bioprinting of iPSC-derived tissues
• Design and implement research studies and related programs, including planning, managing, producing and analyzing the data. The candidate is expected to lead these efforts.
• Communicate with wet lab scientists in the day-to-day activities including but not limited to the data collection, quality control, data cleaning, data analysis, and presentation.
• Extensive use of induced pluripotent stem cell-derived cell types in experiments
• Histology, biochemical analysis, -omics, and electrophysiology experiments of iPSC-derived tissues
• Prepare manuscripts and oversee submission
• Lead grant applications in the field of neurosciences
• Maintain safe and clean lab spaces used
• Mentor and teach graduate, undergraduate and Co-op students

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree