SRA DNA Encoded Library Technology - (Brisbane, CA)

Nurix•Brisbane, CA

8d•$101,690 - $146,679•Onsite

About The Position

We are seeking a talented and motivated chemist to join our Discovery Chemistry team and contribute to the design and synthesis of DNA-encoded libraries (DELs). This hands-on position offers the opportunity to shape Nurix’s DEL-based lead discovery platform, working at the interface of chemistry, biology, and automation.

Requirements

B.S. or higher in Chemistry, Biochemistry, or Medicinal Chemistry.
2–5 years of industrial experience (title determined by experience).
Strong background in synthetic organic chemistry.
Hands-on laboratory experience synthesizing DNA encoded libraries.
Familiar with the overall DNA-Encoded Library Technology workflow operations.
Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).

Nice To Haves

Experience working in the drug discovery field – drug design, synthesis, and SAR based hit-to-lead optimization.
Experience working with high-throughput analytical and purification systems relevant to DEL-applications.
Experience working with molecular biology tools (PCR, qPCR, Western Blot)

Responsibilities

Design and validate novel DEL library builds.
Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space.
Construct DEL libraries to support the in-house library production efforts.
Work with external partners to support our DEL synthesis and hit follow up strategies.
Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning and hit-optimization.
Contribute to platform automation and technology development efforts.
Present results, document workflows, and contribute to scientific and strategic planning within the Discovery Chemistry organization.