Research Associate II, Technical Operations
About The Position
A-Alpha Bio is seeking a Research Associate II to support the Technical Operations team in executing its AlphaSeq assay. The role involves DNA and yeast library construction, matings, next-generation sequencing, cell sorting, and flow cytometry to support the interrogation of protein-protein interactions. The ideal candidate is highly organized, attentive to detail, and interested in running screening assays at scale. The position is onsite in Seattle, Washington, and is not open to remote applicants. It reports to the Manager II, Technical Operations. A-Alpha Bio is an early-stage, rapidly growing biotechnology platform company building experimental data resources for AI-driven protein engineering and applying its data and models to therapeutic discovery and engineering. The work environment is described as fast-paced, highly dynamic, and interdisciplinary.
Requirements
- Bachelor’s degree in a relevant field with at least 2 years of relevant postbaccalaureate laboratory experience in the biotechnology industry, or an equivalent combination of education and experience.
- Proficiency in standard molecular biology techniques, including DNA extractions, quantitative PCR, Gibson assembly, and fragment analysis.
- Experience with multi-parametric flow cytometry.
- Experience in a high-throughput screening or manufacturing environment.
- Experience working within a LIMS/ELN.
- Strong work ethic, good organizational skills, team orientation, and exquisite attention to detail.
- Flexibility in day-to-day schedule and willingness to work outside standard hours when necessary, including weekends.
Nice To Haves
- Operator experience in a regulated environment (CLIA, cGXP, etc.).
- Hands-on experience with Illumina or ONT NGS platforms.
- Experience with cell sorting.
- Experience using yeast as a model organism.
- Experience with Benchling as a platform.
- Experience using lab automation.
Responsibilities
- Execute DNA library construction.
- Perform yeast transformation and matings, cell sorting, and flow cytometry.
- Execute DNA library preparation and sequencing workflows for Oxford Nanopore Technologies and Illumina platforms.
- Support the development and optimization of standard operating procedures for existing and new experimental workflows.
- Develop a foundational understanding of and executional expertise in Technical Operations methods.
- May contribute to project teams, execute project-related tasks, and/or train new Research Associates.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
