Research Associate II, Horns Lab

Arc Institute • Palo Alto, CA

1d • Onsite

About The Position

We are seeking a Research Associate II to join the Horns Laboratory at the Arc Institute. In this position, you will contribute to developing the next generation of platform technologies for monitoring and manipulating mammalian cells, and gain expertise in molecular biology, cell engineering, and genomics. You will have the opportunity to work with world-leading scientists in relevant fields, including single-cell genomics, computational biology, and molecular engineering. This position offers a unique chance for a highly motivated and curious researcher to work on cutting-edge molecular technologies at the intersection of synthetic biology and genomics. Some of the relevant projects extend from our recent work in developing and using cellular RNA exporters to non-destructively monitor cell dynamics and deliver mRNA between cells. This is a great stepping stone for candidates looking to enroll in a PhD program in the future, as you will be involved in designing projects from the ground up and co-authoring papers. The ideal candidate must have a strong background in molecular biology and mammalian cell culture, and will learn to apply their skills to building novel molecular technologies.

Requirements

• BS/MS or equivalent professional experience in cell & molecular biology, biochemistry, bioengineering, or similar field.
• 2+ years of relevant experience in an academic or industry setting (including independent lab work during your undergraduate studies).
• Extensive hands-on experience with standard molecular biology techniques, such as cloning, PCR, qPCR, or plasmid preparation.
• Proficiency with mammalian cell culture and transfections.
• Strong critical thinking and problem-solving skills.
• Strong oral and written communication skills.
• Highly motivated, curious, and a team player.
• Explicitly wish to use this experience to gain entry into a PhD program and are able to provide a minimum 2-year commitment to build a portfolio of work to support you in that endeavor.

Nice To Haves

• NGS library preparation
• Experience with pooled / CRISPR screens
• Mammalian cell engineering (e.g. selection, cell-based assays using flow cytometry, microscopy)
• Ability to analyze large and complex data sets using Python, R, or similar tools.

Responsibilities

• Utilize a wide array of molecular biology techniques, such as restriction cloning, Gibson assembly, DNA/RNA isolation, cDNA synthesis, PCR, qPCR, NGS library preparation, and more.
• Conduct tissue culture and transfection-based experiments, including microscopy and flow cytometry readouts.
• Independently carry out cell culture experiments and molecular biology assays.
• Assist with research planning, execution, analysis, troubleshooting, and data interpretation with a high degree of independence and continued support from the rest of the team.
• Analyze and present data at internal subgroup meetings and seminars.
• Maintain an organized and detailed lab notebook.
• Assist with organizing and managing laboratory resources, including ordering supplies, managing inventory, and maintaining equipment.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Associate degree