Research Associate II/Senior Research Associate
About The Position
SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. The Research Associate II/Senior Research Associate will assist in downstream protein purification, protein characterization, and process development. The position will directly report to a Downstream lead and assist in downstream process development and tech transfer to a GMP manufacturing facility. In this role, the individual will assist and operate both routine and advanced analytical instruments as well as protein purification systems. This position is full-time onsite at our new Bothell, WA location. This role may occasionally need to work outside normal work hours.
Requirements
- MS or BS in Protein Science, Chemical Engineering, Biochemistry or a related field and relevant pharmaceutical or biotech experience
- Research Associate II - requires 2+ years of industry experience
- Senior Research Associate - requires BS with 5+ years of experience or MS degree with 3+ years of industry experience
- Experience with protein chromatography and filtration methods, and protein analysis techniques
- Ability to execute SOPs and biophysical assays, and experiments designed for process development of pipeline molecules independently
- Hands-on experience in: ÄKTA Protein Purification Systems and Unicorn software
- Hands-on experience in: SEC-HPLC/UPLC
- Hands-on experience in: Purification Process Development
- Hands-on experience in: Crossflow and Tangential Flow Filtration techniques
- Hands-on experience in: Column packing / unpacking
- Hands-on experience in: Viral inactivation and viral filtration process development / Viral clearance study
- Hands-on experience in: Low endotoxin production run
- Hands-on experience in: Process scale-down/scale-up
Responsibilities
- Assist in downstream process development of molecules in pre-clinical and clinical pipelines. Process development activities include buffer preparation, chromatography method development and execution, TFF, and filtration operations and development
- Assist in performing routine purifications and analytical assays to support cell-line development, upstream, analytical, and formulation groups
- Execute development experiments to produce scalable and robust purification processes via affinity chromatography, IEX, HIC and CHT, etc, using the ÄKTA FPLC platform. Execute development experiments to produce scalable and robust viral inactivation, viral filtration and tangential flow filtration process
- Generate low endotoxin production runs for pre-clinical studies
- Perform routine HPLC/UPLC, CE, cIEF, octet, ELISA and other biophysical techniques to support upstream, downstream, and formulation process development
- Compile, analyze, and report data for process development, tech transfer documentation, and other internal partners
- Author standard operating procedures for biophysical assays and standard workflows
- Participate in timeline planning
- Other duties as assigned
Benefits
- 100% paid employee premiums for medical/dental/vision
- STD
- LTD
- 401(k) plan with a 50% company match of up to 3%
- 15 PTO days per year
- sick leave
- 11 paid holidays
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
