Research Associate II / Senior Research Associate, Protein Science
About The Position
SystImmune is seeking a Research Associate II or Senior Research Associate to join the AIDD Protein Science Automation team in Bothell, WA. This is a newly created position established to benchmark and operate the company’s antibody screening workflow. The Research Associate will provide the experimental capacity to run cell-free antibody and protein expression, purification, primary screening, and candidate confirmation, while generating reproducible protocols that can be transferred to automation. This role is focused on wet-lab experimentation in protein science and assay development. The RA will contribute to setting up and building out the new automation wet lab. The successful candidate will independently execute reproducible cell-free protein synthesis, purification, and assay workflows with defined controls and SOPs. You will own routine screening batches, deliver consistent candidate data, and transfer validated methods to automation.
Requirements
- Bachelor’s or Master’s degree in Molecular Biology, Biochemistry, or a related field.
- Research Associate II requires bachelor’s degree and 2+ years of industry experience.
- Senior Research Associate requires bachelor’s degree with 5+ years or master’s degree with 3+ years of industry experience.
- Hands-on recombinant protein expression and purification experience, preferably with antibodies or antibody fragments.
- Experience with protein assays such as AlphaLISA, ELISA, BLI, SDS-PAGE, or comparable methods.
- Strong experimental design, assay troubleshooting, data analysis, and documentation skills.
- Completion of standard laboratory safety and data-integrity training upon hire. No external certification is required.
Nice To Haves
- Experience with cell-free protein synthesis (CFPS).
- Experience with magnetic-bead purification and AKTA chromatography.
- Experience with Octet BLI instrumentation and BMG plate readers.
- Experience with assay miniaturization.
- Experience with automated liquid handlers or laboratory robotics.
- Experience with barcode tracking or a laboratory information management system (LIMS).
Responsibilities
- Prepare DNA templates and run cell-free expression reactions for antibodies, antibody fragments, and other proteins.
- Perform affinity or magnetic-bead purification, quantification, and protein quality assessment.
- Run AlphaLISA or ELISA primary screens and support BLI confirmation.
- Own routine experimental setup, assay execution, data QC, repeat decisions, and protocol optimization within approved experimental plans.
- Define controls, acceptance criteria, repeat rules, plate maps, and data-review templates.
- Maintain reagents, experimental records, SOPs, and batch documentation.
- Generate reproducible protocols and support the transfer of validated methods to automation.
- Contribute to setting up and building out the new automation wet lab and its robot-based workflows.
Benefits
- 100% paid employee premiums for medical/dental/vision
- STD
- LTD
- 401(k) plan with a 50% company match of up to 3%
- 15 PTO days per year
- sick leave
- 11 paid holidays
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
