Research Associate II - Senior Research Associate I, Therapeutic Translation
About The Position
Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures, and have raised over $150M to date. We are seeking a motivated and creative Research Associate to join our Therapeutic Translation Team. In collaboration with members of the Therapeutic Translation, Cellular Models and Automation teams, you will design, validate and execute high-throughput experiments to characterize and optimize therapeutic gene editing proteins. Your work will be foundational for expanding our gene editing toolbox and translating these advances to new therapeutic opportunities. The ideal candidate will have experience with molecular biology, mammalian cell culture and NGS preparation workflows. This is an excellent opportunity to work cross-functionally with a diverse team of experts across machine learning, protein design, cell biology, gene editing and laboratory automation.
Requirements
- BS degree in Molecular Biology, Biochemistry, Cell Biology, or a related field with 2 - 4 years of experience or a MS degree within the same fields and 0 - 2 years of experience
- Hands-on experience with molecular biology & cloning workflows
- Hands-on experience with mammalian cell culture & maintenance
- Conceptual understanding of illumina NGS library preparation & QC
Nice To Haves
- Experience with CRISPR and/or mammalian cell-based gene editing assays
- Experience using Benchling as an electronic lab notebook and LIMS system
- Experience with high throughput and/or pooled screening workflows
- Experience with the design or execution of NGS-based assays and analysis workflows
- Experience analyzing large experimental datasets (i.e. Python, SQL, JMP)
- Understanding of the key concepts and challenges related to the field of genetic medicine, gene editing systems, DNA repair, etc.
Responsibilities
- Design, validate and execute end-to-end assays to measure on- and off-target activity of novel gene editing systems using a combination of targeted and genome-wide analytical methods
- Maintain organized tracking of physical samples, reagents, consumables, and assay materials to support efficient high-throughput screening operations, including inventory management, sample traceability, procurement coordination
- Compile and analyze data to inform critical go/no-go decisions, and clearly present conclusions and rationale to stakeholders across the organization
- Collaborate with interdisciplinary teams to optimize engineered protein candidates for therapeutic applications
- Stay up to date on the latest developments in gene editing technology
Benefits
- High-growth opportunity with meaningful impact on the future of protein design
- Competitive compensation package with equity participation
- 401(k) with a strong employer match
- Comprehensive benefits including health/dental/vision insurance
- Generous PTO policy and commitment to work-life balance
- Professional development opportunities in a cutting-edge field at the intersection of AI and biology
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
