Research Associate I/II, Formulation Development

Arcturus Therapeutics Inc•San Diego, CA

10d•$34 - $52•Onsite

About The Position

Arcturus Therapeutics is seeking a temporary Research Associate I/II to join their Formulation Team at their Headquarters in San Diego, CA. This role will support scale-up, manufacturing, and characterization of lipid nanoparticle-based nucleic acid formulations to support their emerging research pipeline. The ideal candidate will have a willingness to learn and contribute to formulation production and purification processes.

Requirements

2+ years of relevant formulation development experience in a life science, pharmaceutical company, or academic lab setting.
Hands on experience working with liquid, frozen, and/or lyophilized dosage forms and related biophysical and chemical analytical methods such as dynamic light scattering.
Record experiments and results in laboratory notebooks (including all electronic systems) in accordance with lab procedures in sufficient detail that co-worker can repeat experiment and interpret results in a timely manner.
Attention to details, ability to think ahead and strong communication skills.
Self-motivated team player excels in a highly innovative, collaborative, and fast-paced environment.

Nice To Haves

Experience with nucleic acid-based and/or lipid nanoparticle formulation development is a major plus.
Experience with TFF (Tangential Flow Filtration), dead-end filtration, and/or fill/finish is a plus.

Responsibilities

Develop nucleic based formulations including complex nanoparticle formulations to support in vitro and in vivo studies for different programs.
Conduct process development of mRNA-LNP drug product to enable successful production of large-scale drug product in internal and external manufacturing sites.
Perform process-related investigations, identify root causes of process/manufacturing discrepancies, evaluate systems for trends and adverse findings, and implement appropriate steps to ensure process robustness.
Perform formulation stability studies, contact material compatibility, in-use compatibility study, and accelerated stability studies.
Maintain proper documentation of all experimental procedures and results, including batch records, protocols, Standard Operating Procedures (SOPs) and other manufacturing related documentations.
Prepare technical reports and presentations which summarize procedures, study results, and data interpretation as needed.
Deliver high quality results in an accurate and a time sensitive manner.
Perform other activities as needed.