Research Associate - Host-Pathogen Interactions

Texas Biomedical Research Institute•San Antonio, TX

7d•Onsite

About The Position

We are seeking a detail-oriented and highly motivated Research Associate to support innovative research focused on host-pathogen interactions using the simian immunodeficiency virus (SIV) rhesus macaque model. In this role, you will provide critical laboratory and data management support for multiple NIH-funded HIV/AIDS research projects investigating viral persistence, immune responses, transcriptomic, metabolomic and epigenetic changes and neurocognitive disease. The successful candidate will prepare and process blood and tissue samples for molecular and cellular analyses, perform a wide range of immunology and molecular biology techniques, maintain valuable biorepositories, and collaborate closely with a multidisciplinary research team.

Requirements

Bachelor's degree in Biology, Microbiology, Immunology, Molecular Biology, Biomedical Sciences, or a related field required.
Four (4) years of relevant laboratory experience with a bachelor's degree, or Two (2) years of relevant laboratory experience with a master's degree.
Strong attention to detail and excellent laboratory technique.
Ability to safely handle infectious agents, blood, biohazardous tissues, and laboratory chemicals while following established biosafety procedures.
Excellent organizational, time management, and documentation skills.
Strong written and verbal communication skills with the ability to work effectively both independently and within a collaborative research team.
Proficiency with Microsoft Office and standard scientific software applications.
Commitment to maintaining laboratory safety, quality standards, and scientific integrity.

Nice To Haves

Master's degree in a related scientific discipline preferred.
Experience with molecular biology techniques, including DNA/RNA extraction, PCR, cloning, and gene expression analysis.
Experience with cell and tissue culture using aseptic techniques.
Experience with flow cytometry and fluorescence-activated cell sorting (FACS).
Experience with Ficoll separation of blood components.
Experience with immunofluorescence, Western blotting, and microscopy.
Experience with tissue processing and biobanking.
Experience with next-generation sequencing sample preparation (e.g., ATAC-seq, spatial transcriptomics, single-cell technologies).
Experience with laboratory information management and sample tracking systems.

Responsibilities

Prepare blood and tissue samples for nucleic acid extraction, including DNA, total RNA, microRNA, and long non-coding RNA (lncRNA) analyses.
Perform total RNA extraction for gene expression, DNA methylation, and microRNA studies.
Process and embed tissues (including intestine, lymph nodes, adipose tissue, and brain) in OCT for spatial transcriptomics and other advanced imaging applications.
Isolate and prepare epithelial cells, lamina propria cells, lymph node cells, adipose tissue cells, PBMCs, microglia, astrocytes, and other primary cell populations.
Extract DNA and RNA from tissues and blood samples for downstream molecular analyses.
Prepare samples for spatial transcriptomics, ATAC-sequencing, single-cell applications, and other next-generation sequencing technologies.
Perform multicolor flow cytometry staining, acquisition, and analysis on blood and tissue-derived cell populations.
Prepare cell suspensions for fluorescence-activated cell sorting (FACS).
Conduct molecular biology assays, including real-time RT-qPCR, combined in situ hybridization and immunofluorescence, immunoprecipitation and Western blotting, luciferase reporter assays, and molecular biology techniques such as molecular cloning, plasmid preparation, bacterial culture, and cell transfection.
Assist with neurobehavioral testing of rhesus macaques using CANTAB and Wisconsin General Testing Apparatus (WGTA) systems, including data collection and analysis.
Process, bank, and archive plasma, tissues, and cellular specimens in liquid nitrogen and ultra-low temperature freezers.
Maintain laboratory databases, frozen sample inventories, and biorepository records.
Monitor laboratory equipment and freezer conditions to ensure sample integrity.
Order laboratory supplies, maintain inventory, and ensure laboratory organization, safety, and compliance.
Assist with shipping and receiving infectious and noninfectious biological materials in accordance with institutional and regulatory requirements.
Prepare stock solutions, controlled substances, and antiretroviral medications for Veterinary Medicine.
Assist with the preparation and maintenance of IACUC protocols and other laboratory regulatory documentation.
Assist with coordinating PET/CT imaging (internal) and magnetic resonance imaging (Mobile MRI services- external) of rhesus macaques.

Benefits

Comprehensive health, dental, vision, and life insurance coverage for you and your family—including pet insurance options.
Competitive employer-funded retirement plan with 6% contributions starting on day one, increasing with years of service.
Generous paid time off, including 14 paid holidays and a paid Winter Recess (from the last week of December through New Year’s).
Paid time off for short-term illness and mental wellness, helping you take the time you need when life happens.
Volunteer Time Off (VTO) to encourage giving back to the community.
Paid parental leave to support you and your growing family.
Flexible work arrangements that support a strong work-life balance.
On-site medical clinic, wellness incentives, and prescription support programs designed to make care more accessible and affordable.
On-site fitness center and wellness programs to help you stay active and healthy.
Relaxed dress code so you can feel comfortable and be yourself at work.
Dynamic learning environment with professional development opportunities, mentorship, tuition reimbursement, and leadership programs to support your growth.