Research Associate, Chemical Development

Novo Nordisk•Boulder, CO

1d•Onsite

About The Position

The Boulder Site is home to the specialized technical operations/CMC team for oligonucleotides and RNAi therapeutics. The CMC team works alongside Quality, Regulatory, Technical Operations and RNAi Early Development professionals at our Boulder, Colorado facility and works closely with our teams in Lexington, Massachusetts. Together, we are driving change. Are you ready to make a difference. The Position Novo Nordisk Global Nucleic Acid Therapies (GNAT) is seeking highly motivated scientists to join its CMC Chemical Development team in Boulder, Colorado. The candidate will be expected to be a key technical resource developing innovative solutions for scalable syntheses, work-up, purifications, and isolations of oligonucleotides, establishing improvements in purity, yield, reproducibility, throughput and environmental impact. The successful candidate will ideally have a strong organic chemistry understanding with exposure to principles of process development, optimization, scale up and tech transfer into a manufacturing setting. This position will support therapeutic programs in multiple disease areas and will contribute to the development of scalable processes supporting Novo Nordisk oligonucleotide programs. Qualified candidates will be expected to work well in a collaborative team environment and be able to independently execute research across a wide range of oligonucleotide and organic chemistry projects.

Requirements

BA/BS or Master’s degree in Chemistry, Biology or related field with 0 years of industrial experience, or a High School Diploma with 8+ years relevant lab experience
Ability to follow technical instructions with some independence
Demonstratable laboratory skills in synthetic organic chemistry and/or oligonucleotide synthesis, characterization, and purification
Solid understanding of synthetic organic chemistry and/or oligonucleotide relevant reactions and mechanisms
Detail-oriented in both data analysis and project timelines
Self-motivated with a proactive mindset
Excellent writing and communication skills
Demonstrated ability to work independently and with cross-functional teams
Ability to thrive in a multi-disciplinary and fast-paced research environment with tight deadlines

Nice To Haves

Strong organic chemistry understanding with exposure to principles of process development, optimization, scale up and tech transfer into a manufacturing setting.

Responsibilities

Provide research and development support of current chemical development projects utilizing state of the art techniques for preparation and analysis of oligonucleotides or nucleic acids
Conduct laboratory work in safe, clean, efficient manner that ensures a safe working environment for colleagues
Characterize starting materials, intermediates, and synthesized molecules using common analytical techniques such as HPLC, LCMS, NMR, GC, KF, and UV-Vis
Develop and optimize all elements of chemical transformations including reaction conditions, workup, purification and isolation. Ensure robustness and reproducibility of developed processes
Work within Technical Operations team to optimize current manufacturing processes for key oligonucleotide intermediates and reagents for oligonucleotide synthesis
Document and summarize results in laboratory notebook, and written reports. Capable of drawing valid conclusions from concrete and abstract variables
Contribute to the team’s knowledge through scientific literature review and discussions
Maintain and troubleshoot common laboratory equipment
Support development and authoring of research reports to provide to internal and external manufacturing teams
Ability to complete assignments that meet clearly defined deadlines and time schedules