Radiochemistry Scientist I

Ratio Therapeutics, Inc.•Boston, MA

6d•$105,000 - $125,000

About The Position

Ratio is seeking a Radiochemistry Scientist to join a growing team of scientists working in research and development of novel theranostic agents. This role involves radiolabeling and evaluating our proprietary TRILLIUM™ platform, which combines pharmacokinetic modulation with advanced chelation technology. The goal is to develop proprietary small molecule targeting agents that can attack a wide range of cancer targets. Additionally, the successful candidate will partner in the development of many theranostic vectors and isotopic pairs as well as extensive use of alpha emitters with our proprietary MACROPA™ chelator for alpha targeted radiotherapy. The ideal candidate will enjoy working in a collaborative, fast-paced environment and be skilled in using radioisotopes for molecular imaging and targeted radiotherapy.

Requirements

Ph.D. in chemistry or related field is required
Post-graduate radiochemistry experience is highly preferred (post-doc or otherwise)
Working knowledge of organic and analytical chemistry
Working knowledge of radiochemistry and competency working with radioactive materials
Some publications in the field
Ability to work well both independently and as part of a team
Strong communication skills, including proficiency in English (both written and oral, as demonstrated by publication record)
Demonstrated ability to prioritize, multitask, and troubleshoot problems
Demonstrated ability to readily acquire new skills and techniques
Must be able to lift 45 lbs. (handling of lead and tungsten vial/syringe shields)

Nice To Haves

Experience with radiometal manual synthesis, including 111In, 68Ga, 64Cu, 90Y, 177Lu, and 225Ac among others
Experience with radiopharmaceutical manufacturing and testing for animal and/or human use
Experience working in a CMC environment to help guide preclinical R&D strategy

Responsibilities

Develop radiolabeling methods for small molecules and biologics
Develop chromatographic methods to analyze and purify radiolabeled compounds (HPLC, GC, radio-TLC, etc.)
Work to become the company’s Radiation Safety Officer
Develop formulations suitable for use in animal and human studies
Conduct in vitro assays to evaluate and optimize stability of radiolabeled compounds
Translate radiolabeling methods to automated synthesis units
Aseptically prepare radiolabeled products for preclinical studies
Conduct quality control testing of products
Maintain clear and accurate records and perform relevant lab maintenance and calibrations
Stay up to date on current literature/radiolabeling methods
Compose and follow standard operating procedures
Interpret data, recognize aberrant results, and propose explanations and next steps
Summarize data for reports, patents, and presentations