Quantitative Systems Pharmacology Manager

Gilead Sciences • Foster City, CA

1d

About The Position

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers. We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come.

Requirements

• 6+ Years with BS
• 4+ Years with MS
• 0+ Years with PhD/PharmD
• Proficiency in mathematical and computational skills needed for QSP modeling work, including but not limited to ordinary differential equations, linear algebra, statistics, optimization, and parameter inference
• Relevant education in computational/systems biology, physics, engineering, or computer science
• Proficiency in relevant software and programming languages which may include python, R, C++, Julia, or MATLAB and MATLAB SimBiology (preferred)
• Basic understanding of molecular and cellular biology including for example concepts from immunology, oncology, virology, cellular signaling, etc.
• Basic understanding of concepts of drug development
• PhD or PharmD degree in a relevant area of research

Nice To Haves

• Experience with QSP software and Bioinformatics tools for informing QSP models
• Familiarity with other modeling techniques: ABMs, PDEs, SDEs, SSA, graph theoretical methods, information theoretical methods, Boolean networks, etc.
• Familiarity with methodologies for Bayesian parameter inference
• Expert knowledge in one or more relevant disease areas (oncology, inflammation, virology)
• Machine learning and AI expertise (LLMs, classical methods for regression or classification)
• Application development experience (e.g. in MATLAB AppDesigner)
• Experience with pharmacokinetic/pharmacodynamic modeling in small molecules and biologics or other pharmacometric modeling experience

Responsibilities

• Develop QSP models for one or more disease areas incorporating available in-house and published data
• Regularly communicate with cross-functional teams to develop and periodically update modeling strategy to ensure timely and impactful execution of modeling goals
• Present model findings to clinical teams and incorporate feedback as needed
• Provide expert guidance across teams as needed
• Contribute to regulatory documents using the appropriate level of documentation and reproducibility
• Maintain accurate records including data, assumptions, parameter values, model changes, etc. while developing models
• Author manuscripts describing model development and findings as needed
• Present modeling work externally at conferences and working groups
• Create Inclusion - knowing the business value of diverse teams, modeling inclusion, and embedding the value of diversity in the way they manage their teams.
• Develop Talent - understand the skills, experience, aspirations and potential of their employees and coach them on current performance and future potential. They ensure employees are receiving the feedback and insight needed to grow, develop and realize their purpose.
• Empower Teams - connect the team to the organization by aligning goals, purpose, and organizational objectives, and holding them to account. They provide the support needed to remove barriers and connect their team to the broader ecosystem.

Benefits

• company-sponsored medical, dental, vision, and life insurance plans
• discretionary annual bonus
• discretionary stock-based long-term incentives (eligibility may vary based on role)
• paid time off

What This Job Offers

• Job Type: Full-time
• Career Level: Manager
• Number of Employees: 5,001-10,000 employees