2027 Future Talent Program - Protein & Structural Chemistry - Intern

MerckBoston, MA
$39,108 - $111,111Onsite

About The Position

The Future Talent Program features internships that last up to 12 weeks and will include one or more projects. These opportunities in our Research and Development Division can provide you with great development and a chance to see if we are the right company for your long-term goals. For you: These positions in our Company's Research Labs will provide you with a great development opportunity and a chance to see if we are the right company for your long-term goals. For us: We get to meet the best and brightest individuals who represent the future of scientific endeavor in the US. We are seeking candidates with a passion for scientific research, excellent academic performance, communication skills, teamwork, and the ability to work in a multi-functional environment. A strong science background in applied biology, biochemistry, or chemistry with research in a laboratory setting is essential. Applicants with previous research experience in the listed areas are highly preferred. You will be provided with laptops and have access to state-of-the-art lab equipment as necessary to perform the role. This is a paid internship targeted to start in June 2027 and run for 10-12 weeks. Potential involvement in a scientific publication may occur as a result of the research undertaken during the internship. The department of Protein & Structural Chemistry is offering internships in the following discipline: Structural Chemistry. The Structural Chemistry groups use X-ray crystallography and Cryo-electron microscopy to determine structures of drug/target complexes, biologics, and other relevant biological macromolecules to enable structure-based drug discovery. The successful candidate will work to support drug discovery with structural information using some or all of the following methods: preparative protein purification, characterization using SDS-PAGE, spectroscopic and analytical chromatographic methods, biochemical and biophysical pre-crystallization assays, crystallization screening and crystal optimization, crystal harvesting, grid preparation for Cryo-EM, and data collection, processing, and structure determination and critical analysis of protein-ligand structural data. Interns will be responsible for accurate electronic notebook recording, safe laboratory practices, and presentation of data and their interpretation to a team of scientists. The intern will also attend departmental and team meetings to gain a wider perspective of the drug development process in the pharmaceutical industry.

Requirements

  • Pursuing BS/BA or Master’s/Ph.D. degree in related field with demonstrated interest/experience in research areas relevant to the drug discovery process.
  • Basic laboratory skills and research experience such as: structural biology, protein biochemistry, biophysics, BioNMR, mass spectrometry, molecular biology, protein expression and purification, protein characterization using biochemical and biophysical techniques, and safe lab practices.
  • Completed at least two years of studies toward BS/BA degree or at least 1 year towards Master’s/PhD at time of internship.
  • Currently enrolled in an academic program at the time of the application and be continuing education for at least 1 semester once internship completes.
  • Available for full-time employment for 10-12 weeks during the months of June - August 2027.

Nice To Haves

  • Previous research experience in applied biology, biochemistry, or chemistry.
  • Significant interest in protein structure/function.
  • Experience with preparation of challenging biological macromolecules such as membrane proteins, or characterizing proteins using functional assays or techniques that measure ligand binding.
  • GPA of 3.0 or higher.

Responsibilities

  • Support drug discovery with structural information using methods such as preparative protein purification, characterization using SDS-PAGE, spectroscopic and analytical chromatographic methods, biochemical and biophysical pre-crystallization assays, crystallization screening and crystal optimization, crystal harvesting, grid preparation for Cryo-EM, and data collection, processing, and structure determination and critical analysis of protein-ligand structural data.
  • Accurate electronic notebook recording.
  • Safe laboratory practices.
  • Presentation of data and their interpretation to a team of scientists.
  • Attend departmental and team meetings to gain a wider perspective of the drug development process in the pharmaceutical industry.
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