Process Development Sr Scientist

Amgen • Thousand Oaks, CA

1d • $126,066 - $170,560

About The Position

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Requirements

• Doctorate degree
• Master’s degree and 2 years of Scientific experience
• Bachelor’s degree and 4 years of Scientific experience

Nice To Haves

• Ph.D. in Analytical Chemistry, Biochemistry with emphasis in mass spectrometry, chromatography, electrophoresis, or other analytical technique
• 2 or more year’s post-PhD experience in the pharmaceutical or biotech industry in process and product development and drug substance and drug product analytical method development
• Documented theoretical knowledge and hand-on experience in peptide mapping of proteins, intact and reduced LC-MS analysis for identification and quantification of chemical modifications
• Training and experience of operating Thermo Q-Exactive mass spectrometers, Agilent mass spectrometers, and Agilent and Waters HPLCs and UHPLCs and associated data processing software (including empower, chromeleon, biopharmafinder, mass hunter, etc.)
• Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects
• Knowledge of statistical processing of data, including related software like Excel, Spotfire & JMP
• Knowledge of programming using R, Python, C++, or machine learning languages
• Experience with automation, robotics, or liquid handlers
• Demonstrated proficiency in solving complex problems, ability to work independently, proactively seek outside resources and collaborate, self-starter and team player with strong leadership and decision-making skills capable of providing mentorship to junior staff

Responsibilities

• Identifying and characterizing attributes of therapeutic proteins and synthetic molecules using advanced analytical techniques
• Develop and apply novel sample preparation and analytical methods for analysis of therapeutic proteins and synthetic molecules with emphasis on chromatography, electrophoresis, and/ or mass spectrometry (LC-MS/MS)
• Assess a variety of quality attributes of therapeutic proteins with emphasis on chemical modifications including glycosylation, oxidation, deamidation, aspartate isomerization, hydroxylation and others
• Work in an analytical group equipped with a variety of chromatographic and electrophoretic systems and mass spectrometry platforms
• Communicate (verbal and in written) scientific concepts and results
• Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in drug development and regulatory filings
• Work collaboratively with other scientists on multidisciplinary teams
• Work independently in advancing projects and studies within required deadlines
• Actively create or contribute to patent and publications
• Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree