Process Development Research Scientist

Mass General Brigham•Boston, MA

4d•$60,000 - $96,000•Onsite

About The Position

The Massachusetts General Hospital Cancer Center’s Process Development Laboratory seeks a full-time Process Development Scientist I to support and advance its translational cell and gene therapy research platform. The Process Development Laboratory is a highly integrated, innovation-driven facility dedicated to translating next-generation cellular immunotherapy and gene engineering technologies into clinically deployable manufacturing solutions. This position offers an exceptional opportunity for an independent and motivated scientist to serve as a scientific lead within a multidisciplinary translational team, working at the interface of biology, engineering, manufacturing science, and regulatory strategy. The successful candidate will contribute to the design, development, optimization, and clinical translation of novel manufacturing workflows poised for IND-enabling studies and early-phase clinical trials, while operating in a collaborative academic medical center environment.

Requirements

Doctorate Related Field of Study required
Previous Research experience (inclusive of graduate and postdoctoral experience) 5-7 years required
Excellent research skills.
Demonstrated evidence of specific scientific competence in field.
Demonstrated broad knowledge of field.
Evidence of potential for scientific creativity and original thought.
Able to exercise independent judgment and leadership.
Ability to contribute to publications.

Nice To Haves

Demonstrated experience in cell and/or gene therapy research and process development.
Hands-on experience working with primary human cells, preferably immune effector cells.
Strong foundation in cell culture, molecular biology, and translational experimental design.
Experience with CAR T-cell or immune effector cell manufacturing.
Familiarity with CRISPR/Cas-based genome editing technologies.
Experience with viral vector production or gene delivery platforms.
Exposure to cGMP environments, IND-enabling studies, or regulated manufacturing settings.
Experience with closed-system or automated manufacturing platforms.
Prior experience contributing to regulatory documentation, technology transfer, or validation activities.

Responsibilities

Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field.
Contributes to the design and execution of experiments and/or research projects.
Exercises judgment in selecting methods and technologies to obtain results.
May collaborate with external researchers and/or receive external project funding support.
Presents results and prepares publications.
May assist PI in the training and supervision of other staff.