Process Development Research Scientist
About The Position
The Massachusetts General Hospital Cancer Center’s Process Development Laboratory seeks a full-time Process Development Scientist I to support and advance its translational cell and gene therapy research platform. The laboratory is an integrated, innovation-driven facility focused on translating cellular immunotherapy and gene engineering technologies into clinically deployable manufacturing solutions. The scientist will serve as a scientific lead within a multidisciplinary team working across biology, engineering, manufacturing science, and regulatory strategy. In consultation with a Principal Investigator, the role undertakes and executes a scientific study program intended to culminate in publication. The scientist contributes to the design, development, optimization, and clinical translation of manufacturing workflows for IND-enabling studies and early-phase clinical trials. The role drives research projects scientifically and may demonstrate leadership through obtaining funding, writing, or other recognition. The position also contributes to training and supervising laboratory personnel and administrative tasks as needed. The position does not require patient care.
Requirements
- Doctorate in a related field of study.
- Five to seven years of previous research experience, including graduate and postdoctoral experience.
- Excellent research skills.
- Demonstrated specific scientific competence and broad knowledge in the field.
- Evidence of potential for scientific creativity and original thought.
- Ability to exercise independent judgment and leadership.
- Ability to contribute to publications.
Nice To Haves
- Demonstrated experience in cell and/or gene therapy research and process development.
- Hands-on experience with primary human cells, preferably immune effector cells.
- Strong foundation in cell culture, molecular biology, and translational experimental design.
- Experience with CAR T-cell or immune effector cell manufacturing.
- Familiarity with CRISPR/Cas-based genome editing technologies.
- Experience with viral vector production or gene delivery platforms.
- Exposure to cGMP environments, IND-enabling studies, or regulated manufacturing settings.
- Experience with closed-system or automated manufacturing platforms.
- Prior experience contributing to regulatory documentation, technology transfer, or validation activities.
Responsibilities
- Make intellectual contributions to the scientific strategies of the group or laboratory and act as a subject-matter authority in the field.
- Contribute to the design and execution of experiments and research projects.
- Exercise judgment in selecting methods and technologies to obtain results.
- Design, develop, optimize, and translate manufacturing workflows for cell and gene therapy research toward clinical use.
- Present results and prepare publications.
- May collaborate with external researchers or receive external project funding support.
- May assist the Principal Investigator in training and supervising laboratory staff.
- Support related administrative tasks as necessary.
Benefits
- Comprehensive benefits.
- Career advancement opportunities.
- Differentials, premiums, and bonuses as applicable.
- Recognition programs designed to celebrate contributions and support professional growth.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
