Process Development Associate Scientist

Amgen • Thousand Oaks, CA

8d • $90,443 - $122,363

About The Position

Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Process Development Associate Scientist
What you will do
Let’s do this. Let’s change the world. In this vital role you will be responsible for analytical and biochemical characterization activities for pre-clinical biotherapeutic protein development including assay development for biochemical characterization with emphasis on mass spectrometry and high-pressure liquid chromatography (HPLC), planning and execution of experiments in support of pre-clinical candidate selection, process development and lead molecule characterization. Perform biochemical characterization of the candidate drug products with peptide mapping and intact protein LC-MS analysis.
Specific activities include characterizing candidate molecules to support protein primary structure as well as characterizing drug candidate chemical and post-translational modifications (quality attributes).
Automation platforms and liquid handling systems are used. Generation of technical documents and technical presentations is required.
Analytical laboratory management and general maintenance scheduling repairs and performing method suitability testing of equipment.
This position is also responsible for providing scientific results that support the generation of regulatory submissions, patents, and publications and exploring and evaluating emerging technologies relevant to MS-based characterization of therapeutic proteins.

Requirements

• Master’s degree and 1 year of relevant industrial experience OR Bachelor’s degree and 3 years of relevant industrial experience.
• Master’s or Bachelor’s degree in analytical chemistry, chemistry, biochemistry, pharmaceutical sciences, physical sciences, chemical engineering, or biological sciences.
• Expertise with HPLC and mass spectrometry.
• Expertise with statistical software, including Excel or similar software is recommended.
• Experience within analytical testing or biotech industry, experience to include data analyses, statistical analysis in support of process development, and comparability studies.
• Good problem-solving skills requiring the application of scientific theory.
• Strong laboratory work skills for execution of scientific experiments and interpretation of results.
• Excellent written and oral communication skills for the documentation, presentation, and discussion of scientific results in a fast-paced, multi-disciplinary environment.

Responsibilities

• Responsible for analytical and biochemical characterization activities for pre-clinical biotherapeutic protein development including assay development for biochemical characterization with emphasis on mass spectrometry and high-pressure liquid chromatography (HPLC).
• Planning and execution of experiments in support of pre-clinical candidate selection, process development and lead molecule characterization.
• Perform biochemical characterization of the candidate drug products with peptide mapping and intact protein LC-MS analysis.
• Characterizing candidate molecules to support protein primary structure as well as characterizing drug candidate chemical and post-translational modifications (quality attributes).
• Utilize automation platforms and liquid handling systems.
• Generation of technical documents and technical presentations.
• Analytical laboratory management and general maintenance scheduling repairs and performing method suitability testing of equipment.
• Providing scientific results that support the generation of regulatory submissions, patents, and publications.
• Exploring and evaluating emerging technologies relevant to MS-based characterization of therapeutic proteins.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level