Process Chemist III

Abzena Inc.•Bristol, PA

About The Position

With extensive experience in developing biologics and bioconjugates, Abzena offers a seamless service delivered by fully integrated teams, from early discovery to commercial manufacturing. Forward-thinking and committed, they find the best solution and use the right technologies to design, develop and manufacture products to ensure vital medicines reach patients quickly and safely. Abzena is dedicated to quality excellence and driven to get better treatments to market, efficiently and responsibly by reducing timelines and delivering the highest quality products and services. Abzena is more than a CDMO, they are a responsible and dedicated partner that takes care of products from concept to patient. Abzena is seeking a highly motivated Process Chemist III to join their Process Development team. The successful candidate will lead the development, optimization, and scale-up of synthetic processes for small molecules, linker-payloads, intermediates, and related compounds from early development through cGMP manufacturing. This role requires strong technical expertise, excellent problem-solving skills, and the ability to collaborate effectively with cross-functional teams.

Requirements

Ph.D. in Organic Chemistry with 2+ years of industrial experience, or M.S. in Organic Chemistry with 5+ years of industrial experience
Strong knowledge of synthetic organic chemistry and process development.
Experience with reaction optimization, impurity control, and process scale-up.
Experience with analytical techniques such as UPLC, HPLC, LC-MS, GC, and NMR.
Excellent scientific writing, communication, and presentation skills.
Demonstrated ability to manage multiple projects in a fast-paced environment.

Nice To Haves

Experience in pharmaceutical, biotechnology, or CDMO environments.
Experience supporting cGMP manufacturing campaigns and technology transfer.
Experience with linker-payload synthesis, peptide coupling chemistry, or highly potent compounds is desirable.

Responsibilities

Design, execute, and optimize synthetic routes for small molecules, intermediates, and complex drug-linker compounds.
Develop scalable, robust, and cost-effective manufacturing processes suitable for pilot plant and cGMP production.
Plan and perform laboratory experiments, analyze data, and interpret results to guide process improvements.
Troubleshoot challenging synthetic and scale-up issues using sound scientific principles.
Collaborate with Analytical Development, Manufacturing, MSAT, Quality, Supply Chain, and Project Management teams to ensure successful technology transfer and manufacturing campaigns.
Prepare technical reports, batch records, process descriptions, risk assessments, and technology transfer documentation.
Maintain accurate laboratory notebooks and ensure documentation complies with company and regulatory standards.
Mentor junior scientists and provide technical guidance on experimental design and process development.
Support client meetings by presenting technical data and project updates.
Contribute to continuous improvement initiatives focused on safety, quality, efficiency, and sustainability.