Principal/Sr. Principal Scientist - Development
About The Position
The Department of Translational Safety at Genentech provides scientific leadership and plays an active role in the process of drug development from the discovery phase through marketed products. We are seeking a Principal/Sr Principal Scientist in Toxicology to support drug development. This role will involve working in a collaborative team environment as part of the comprehensive safety assessment of Genentech therapeutics by providing toxicology representation to programs. The successful candidate for Principal/Sr Principal Scientist will provide scientific leadership and play an active role in the process of drug development, with a strong emphasis on Genentech’s oncology and cardiovascular, respiratory, and metabolism development project portfolio, which includes small molecules, immunomodulatory biotherapeutics, bi-specific antibodies, ADCs, cancer vaccines and cellular therapeutics. Working in a collaborative team environment, the Principal/Sr Principal Scientist leads the safety assessment of Genentech therapeutics by creating a best-evidence synthesis of existing knowledge and comprehensive investigations of toxicologic activity, strategic planning, and designing/implementing/supervising toxicology studies in support of program advancement.
Requirements
- PhD and post-doctorate or equivalent experience in toxicology or a relevant field along with a minimum of 3+ years relevant experience in the pharmaceutical/biotechnology/CRO industry related to toxicology (for Principal Scientist)
- PhD and post-doctorate or equivalent experience in toxicology or a relevant field along with a minimum of 8+ years relevant experience in the pharmaceutical/biotechnology/CRO industry related to toxicology (for Sr. Principal Scientist)
- Extensive experience in drug development and interaction with global regulatory authorities are required.
- Strong decision-making, complex problem solving, critical data analysis and interpretation, excellent written and verbal communication skills; and the ability to build productive cross-functional collaborations both within and external to Genentech
Nice To Haves
- Experience in oncology and cardiovascular, respiratory, and metabolism therapy areas leveraging different therapeutic modalities such as small molecules, degraders, and ADCs is highly desirable
- Evidence of a consistent and extensive record of impact internally and externally.
- Board certification in toxicology is desirable.
- Experience with cross-functional teams and capability to build productive cross-functional internal and external collaborations are desired.
Responsibilities
- Interdisciplinary project team membership
- Scientific leadership in the design and implementation of safety assessment strategies to support program advancement and decision-making
- Preparation and review of regulatory documentation
- Preparation and review of study reports and manuscripts
- Representation of Genentech in meetings with regulatory authorities
- Investigations into mechanisms of toxicity
- Proactive management of potential safety liabilities and communication of impact to teams and governance committees.
- Mentoring of toxicologists and as needed, team members, and lead or provide support to inter- and intra-departmental initiatives.
Benefits
- Relocation benefits are available.
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
