Principal Software Engineer

eClinical Solutions • Mansfield, MA

1d • Remote

About The Position

eClinical Solutions is transforming clinical development with elluminate®, our Clinical Data Cloud, helping life sciences organizations unify, analyze, and unlock the value of their data faster than ever before. By combining a modern cloud platform with expert data services, we empower smarter decisions across the clinical trial lifecycle—accelerating innovation that ultimately improves patient outcomes. Our engineering teams build enterprise-grade, revenue-generating products at the intersection of cloud, data, analytics, and emerging AI technologies. If you’re excited about building sophisticated software that makes a real-world impact on healthcare, this is the place to do it. As a Principal Full Stack Software Engineer, you will be a technical leader within the elluminate Product Development team. You’ll help design and build the core services and user experiences of a next-generation clinical data and analytics platform—while influencing architecture, engineering standards, and technical direction. This role is ideal for an experienced engineer who enjoys hands-on development, mentoring others, and bringing modern capabilities—including AI-assisted and agentic workflows—into production-grade systems.

Requirements

• Bachelor’s or Master’s degree in Computer Science or equivalent practical experience
• 10+ years in software design and development using the Microsoft technology stack preferred
• Expert-level proficiency in C#, .NET, and ASP.NET (MVC/Web APIs)
• Strong experience building full-stack web applications (Angular, TypeScript, HTML, CSS)
• Solid understanding of software design principles, patterns, and best practices
• Experience across the full Software Development Lifecycle (Agile preferred)
• Proven ability to work independently while collaborating effectively in a fast-paced environment
• Excellent communication, documentation, and technical leadership skills
• Hands-on experience integrating LLM-based services (e.g., OpenAI, Azure OpenAI, or similar) into applications
• Experience using Python and/or .NET alongside AI/LLM workflows
• Familiarity with agent-based or workflow-driven AI architectures is a strong plus
• Understanding of secure and responsible AI usage in enterprise systems

Nice To Haves

• Strong SQL expertise (Microsoft SQL Server preferred), including performance tuning
• Experience with microservices, distributed systems, and cloud platforms (AWS preferred)
• Secure development experience, including awareness of common vulnerabilities and mitigations
• Experience with clinical trial data, life sciences, or regulated SaaS environments
• Experience building data visualizations or analytics-driven user experiences

Responsibilities

• Design, develop, test, and deploy scalable, secure, and highly interactive web applications
• Own and evolve core platform modules, from concept through release and support
• Influence application and system architecture with a focus on performance, reliability, security, and maintainability
• Lead by example through clean, well-tested code, thoughtful design reviews, and pragmatic technical decisions
• Collaborate closely with Product Management, QA, and other engineers throughout the SDLC
• Provide technical mentorship and guidance to other engineers on the team
• Diagnoses and resolves complex production issues across distributed systems
• Ensure solutions meet eClinical Solutions quality standards and applicable industry regulations
• Contribute to technical documentation including design specs, acceptance criteria, and release notes
• Integrating LLMs and AI services into .NET- and Python-based systems
• Designing and implementing AI-assisted workflows, copilots, or intelligent automation features
• Working with agentic AI patterns (e.g., task orchestration, tool-using agents, workflow automation)
• Applying prompt engineering, evaluation techniques, and guardrails to ensure reliability and compliance
• Collaborating with data and platform teams to operationalize AI—not just prototype it

Benefits

• 2025 Top Workplaces USA Award for Remote Work
• Top Workplaces Culture Excellence Awards celebrating exceptional company vision, values, and work-life balance

What This Job Offers

• Job Type: Full-time
• Career Level: Senior