Principal Scientist - Medicinal Chemistry
About The Position
The Principal Scientist will be part of Amgen’s Medicinal Chemistry group, designing, synthesizing, and purifying novel compounds for potential clinical drug development. The role may also involve work with Amgen’s Induced Proximity Platform (IPP), which develops innovative approaches to modulate difficult-to-target diseases using the PROTAC modality. This is an onsite laboratory position at Amgen’s South San Francisco site. The scientist will plan and conduct research, interpret and communicate results, collaborate with other scientists, and may advise colleagues, contribute to publications or patents, participate in scientific meetings, and mentor research associates and laboratory assistants.
Requirements
- Doctorate degree and 2 years of scientific experience, or a master’s degree and 5 years of scientific experience, or a bachelor’s degree and 7 years of scientific experience.
- Excellent collaboration and communication skills, both written and oral.
Nice To Haves
- Doctorate degree in chemistry specializing in organic chemistry and 6 or more years of experience in synthetic organic and medicinal chemistry.
- Experience leading medicinal chemistry teams and delivering candidates for clinical development.
- A consistent and successful drug discovery track record, such as patent inventorship, conference presentations, and peer-reviewed publications.
- Deep understanding of drug discovery and relevant disciplines, such as chemistry, biology, safety, and PKDM.
- Expertise in modern medicinal and synthetic chemistry approaches.
Responsibilities
- Devise and implement scientific research through laboratory experiments.
- Plan detailed procedures for defined projects, including timelines, milestones, methodological approaches, expected results, and necessary resources.
- Review, analyze, and interpret scientific data and results.
- Provide regular updates, documentation, and communication about project results.
- Collaborate with other scientists and stay current with relevant literature and technology developments.
- Advise supervisors and colleagues in areas of expertise, as needed.
- Participate in national and international meetings and provide scientific results that support publications or patents.
- Mentor research associates and laboratory assistants.
Benefits
- Health and welfare plans for staff and eligible dependents.
- Retirement and savings plan with company contributions.
- Medical, dental, and vision coverage.
- Life and disability insurance.
- Flexible spending accounts.
- Discretionary annual bonus program, or a sales-based incentive plan for field sales representatives.
- Stock-based long-term incentives.
- Time-off plans.
- Career development opportunities.
- Flexible work models, including remote and hybrid arrangements where possible.
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What This Job Offers
Job Type
Full-time
Career Level
Principal
